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Cellosaurus MCF-7/5-23 (CVCL_4V44)

[Text version]

Cell line name MCF-7/5-23
Synonyms MCF 7/5-23; MCF 5-23; 5-23
Accession CVCL_4V44
Resource Identification Initiative To cite this cell line use: MCF-7/5-23 (RRID:CVCL_4V44)
Comments Selected for resistance to: ChEBI; CHEBI:41774; Tamoxifen.
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line

PubMed=8244585; DOI=10.1002/ijc.2910550529
Hu X.F., Veroni M., de Luise M., Wakeling A.E., Sutherland R., Watts C.K.W., Zalcberg J.R.
Circumvention of tamoxifen resistance by the pure anti-estrogen ICI 182,780.
Int. J. Cancer 55:873-876(1993)

PubMed=10070856; DOI=10.1038/sj.bjc.6690112
Parisot J.P., Hu X.F., de Luise M., Zalcberg J.R.
Altered expression of the IGF-1 receptor in a tamoxifen-resistant human breast cancer cell line.
Br. J. Cancer 79:693-700(1999)

Other Wikidata; Q54904349
Entry history
Entry creation14-Dec-2015
Last entry update02-Jul-2020
Version number7