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Cellosaurus IGROV(T100r) (CVCL_4V48)

Cell line name IGROV(T100r)
Accession CVCL_4V48
Resource Identification Initiative To cite this cell line use: IGROV(T100r) (RRID:CVCL_4V48)
Comments Selected for resistance to: ChEBI; CHEBI:63632; Topotecan.
Sequence variations Heterozygous for BRCA1 p.Lys654fs*47 (c.1961delA) (from parent cell line).
Heterozygous for SMAD4 p.Gly231fs*10 (c.692delG) (from parent cell line).
Heterozygous for PTEN p.Thr319fs*1 (c.955_958delACTT) (from parent cell line).
Heterozygous for TP53 p.Tyr126Cys (c.377A>G) (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1304 (IGROV-1)
Sex of cell Female
Age at sampling 47Y
Category Cancer cell line

PubMed=9635842; DOI=10.1038/bjc.1998.270
Ma J., Maliepaard M., Nooter K., Loos W.J., Kolker H.J., Verweij J., Stoter G., Schellens J.H.M.
Reduced cellular accumulation of topotecan: a novel mechanism of resistance in a human ovarian cancer cell line.
Br. J. Cancer 77:1645-1652(1998)

Other Wikidata; Q54897390