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Cellosaurus LoVo/irinotecan (CVCL_4V50)

Cell line name LoVo/irinotecan
Accession CVCL_4V50
Resource Identification Initiative To cite this cell line use: LoVo/irinotecan (RRID:CVCL_4V50)
Comments Selected for resistance to: ChEBI; CHEBI:80630; Irinotecan (Camptothecin-11; CPT-11).
Omics: Proteome analysis by 2D-DE/MS.
Sequence variations Homozygous for ACVR2A p.Lys437fs*5 (c.1310delA) (from parent cell line).
APC p.Arg1114Ter (c.3340C>T), p.Met1431fs*42 (c.4289delC) and p.Arg2816Gln (c.8447G>A) (from parent cell line).
KRAS p.Gly13Asp (c.38G>A) (from parent cell line).
SMAD2 p.Ala292Val (c.875C>T) (from parent cell line).
Homozygous for TGFBR2 p.Lys128Serfs*35 (c.383delA) (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Derived from metastatic site: Left supraclavicular lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0399 (LoVo)
Sex of cell Male
Age at sampling 56Y
Category Cancer cell line

PubMed=21289438; DOI=10.1007/s12038-010-0064-9
Peng X.-C., Gong F.-M., Wei M., Chen X., Chen Y., Cheng K., Gao F., Xu F., Bi F., Liu J.-Y.
Proteomic analysis of cell lines to identify the irinotecan resistance proteins.
J. Biosci. 35:557-564(2010)

Other Wikidata; Q54902905