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Cellosaurus K562/NIL-50 (CVCL_4V51)

[Text version]
Cell line name K562/NIL-50
Accession CVCL_4V51
Resource Identification Initiative To cite this cell line use: K562/NIL-50 (RRID:CVCL_4V51)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:52172; Nilotinib (AMN107; Tasigna).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
Disease Blast phase chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C9110)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
Publications

PubMed=22712605; DOI=10.7785/tcrt.2012.500281
Ceylan C., Camgoz A., Baran Y.
Macromolecular changes in nilotinib resistant K562 cells; an in vitro study by Fourier transform infrared spectroscopy.
Technol. Cancer Res. Treat. 11:333-344(2012)

Cross-references
Encyclopedic resources Wikidata; Q54899416
Entry history
Entry creation14-Dec-2015
Last entry update29-Jun-2023
Version number14