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Cellosaurus K562/NIL-50 (CVCL_4V51)

[Text version]

Cell line name K562/NIL-50
Accession CVCL_4V51
Resource Identification Initiative To cite this cell line use: K562/NIL-50 (RRID:CVCL_4V51)
Comments Selected for resistance to: ChEBI; CHEBI:52172; Nilotinib (AMN107; Tasigna).
Derived from sampling site: Pleural effusion.
Sequence variations BCR-ABL1 gene fusion (from parent cell line).
Homozygous for TP53 p.Gln136fs*13 (c.406_407insC) (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line

PubMed=22712605; DOI=10.7785/tcrt.2012.500281
Ceylan C., Camgoz A., Baran Y.
Macromolecular changes in nilotinib resistant K562 cells; an in vitro study by Fourier transform infrared spectroscopy.
Technol. Cancer Res. Treat. 11:333-344(2012)

Other Wikidata; Q54899416
Entry history
Entry creation14-Dec-2015
Last entry update12-Mar-2020
Version number8