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Cellosaurus MCF-7/4-HC (CVCL_4V53)

[Text version]

Cell line name MCF-7/4-HC
Synonyms MCF-7/4-hc; MCF7/4HC; MCF-7/OAP
Accession CVCL_4V53
Resource Identification Initiative To cite this cell line use: MCF-7/4-HC (RRID:CVCL_4V53)
Comments Selected for resistance to: ChEBI; CHEBI:196991; 4-hydroperoxycyclophosphamide.
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line

Frei E. III, Teicher B.A., Holden S.A., Cathcart K.N.S., Wang Y.Y.
Preclinical studies and clinical correlation of the effect of alkylating dose.
Cancer Res. 48:6417-6423(1988)

PubMed=8328987; DOI=10.1016/0006-2952(93)90231-K
Sreerama L., Sladek N.E.
Identification and characterization of a novel class 3 aldehyde dehydrogenase overexpressed in a human breast adenocarcinoma cell line exhibiting oxazaphosphorine-specific acquired resistance.
Biochem. Pharmacol. 45:2487-2505(1993)

Other Wikidata; Q54904348
Entry history
Entry creation14-Dec-2015
Last entry update02-Jul-2020
Version number7