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Cellosaurus HL/CAFdA20 (CVCL_4V55)

[Text version]
Cell line name HL/CAFdA20
Accession CVCL_4V55
Resource Identification Initiative To cite this cell line use: HL/CAFdA20 (RRID:CVCL_4V55)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:681569; Clofarabine (CAFdA).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene deletion; HGNC; 11998; TP53; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
Disease Adult acute myeloid leukemia (NCIt: C9154)
Acute myeloid leukemia (ORDO: Orphanet_519)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0002 (HL-60)
Children:
CVCL_4V56 (HL/CAFdA80)
Sex of cell Female
Age at sampling 36Y
Category Cancer cell line
Publications

PubMed=23421409; DOI=10.1111/cas.12131
Shigemi H., Yamauchi T., Tanaka Y., Ueda T.
Novel leukemic cell lines resistant to clofarabine by mechanisms of decreased active metabolite and increased antiapoptosis.
Cancer Sci. 104:732-739(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4V55
Encyclopedic resources Wikidata; Q54889814
Entry history
Entry creation14-Dec-2015
Last entry update05-Oct-2023
Version number16