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Cellosaurus KMS-11/BTZ (CVCL_4V71)

[Text version]
Cell line name KMS-11/BTZ
Synonyms KMS11/BTZ
Accession CVCL_4V71
Resource Identification Initiative To cite this cell line use: KMS-11/BTZ (RRID:CVCL_4V71)
Comments Population: Japanese.
Characteristics: Produces IgG kappa.
Selected for resistance to: ChEBI; CHEBI:52717; Bortezomib (Velcade).
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; 5722; IGKJ4 + HGNC; 5739; IGKV1-37; Name(s)=IGKV1-37-IGKJ4 (from parent cell line).
  • Gene fusion; HGNC; 5723; IGKJ5 + HGNC; 5816; IGKV3-15; Name(s)=IGKV3-15-IGKJ5 (from parent cell line).
  • Mutation; HGNC; 3690; FGFR3; Simple; p.Tyr373Cys (c.1118A>G); ClinVar=VCV000016342; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 12033; TRAF3; Simple; p.Lys191Leufs*3; Zygosity=Homozygous (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2989 (KMS-11)
Sex of cell Female
Age at sampling 67Y
Category Cancer cell line
STR profile Source(s): JCRB

Markers:
AmelogeninX
CSF1PO13
D5S81810,12
D7S82011,12
D13S31712
D16S5399,13
TH016,9
TPOX12
vWA17,18

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Publications

PubMed=20555361; DOI=10.1038/leu.2010.137
Ri M., Iida S., Nakashima T., Miyazaki H., Mori F., Ito A., Inagaki A., Kusumoto S., Ishida T., Komatsu H., Shiotsu Y., Ueda R.
Bortezomib-resistant myeloma cell lines: a role for mutated PSMB5 in preventing the accumulation of unfolded proteins and fatal ER stress.
Leukemia 24:1506-1512(2010)

Cross-references
Cell line collections (Providers) JCRB; JCRB1642
Cell line databases/resources cancercelllines; CVCL_4V71
Encyclopedic resources Wikidata; Q54900165
Entry history
Entry creation14-Dec-2015
Last entry update05-Oct-2023
Version number11