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Cellosaurus OPM-2/BTZ (CVCL_4V72)
[Text version]
Cell line name |
OPM-2/BTZ
|
Synonyms |
OPM2/BTZ
|
Accession |
CVCL_4V72
|
Resource Identification Initiative |
To cite this cell line use: OPM-2/BTZ (RRID:CVCL_4V72) |
Comments |
Population: Japanese. Characteristics: Produces Ig lambda. Selected for resistance to: ChEBI; CHEBI:52717; Bortezomib (Velcade). Derived from sampling site: Peripheral blood.
|
Sequence variations |
- Mutation; HGNC; 1787; CDKN2A; Simple; p.His83Tyr (c.247C>T) (p.Ala97Val, c.290C>T); ClinVar=VCV000376307; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 3690; FGFR3; Simple; p.Lys650Glu (c.1948A>G); ClinVar=VCV000016331; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6768; SMAD2; Simple; p.Leu87Arg (c.260T>G); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
|
Disease |
Plasma cell myeloma (NCIt: C3242) Multiple myeloma (ORDO: Orphanet_29073)
|
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606)
|
Hierarchy |
Parent: CVCL_1625 (OPM-2)
|
Sex of cell |
Female
|
Age at sampling |
56Y
|
Category |
Cancer cell line
|
Publications | PubMed=20555361; DOI=10.1038/leu.2010.137 Ri M., Iida S., Nakashima T., Miyazaki H., Mori F., Ito A., Inagaki A., Kusumoto S., Ishida T., Komatsu H., Shiotsu Y., Ueda R. Bortezomib-resistant myeloma cell lines: a role for mutated PSMB5 in preventing the accumulation of unfolded proteins and fatal ER stress. Leukemia 24:1506-1512(2010) |
Cross-references |
Encyclopedic resources |
Wikidata; Q54936484
|
Entry history |
Entry creation | 14-Dec-2015 |
Last entry update | 20-May-2021 |
Version number | 9 |
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