ID   OPM-2/BTZ
AC   CVCL_4V72
SY   OPM2/BTZ
DR   cancercelllines; CVCL_4V72
DR   Wikidata; Q54936484
RX   PubMed=20555361;
CC   Population: Japanese.
CC   Characteristics: Produces Ig lambda.
CC   Selected for resistance to: ChEBI; CHEBI:52717; Bortezomib (Velcade).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.His83Tyr (c.247C>T) (p.Ala97Val, c.290C>T); ClinVar=VCV000376307; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3690; FGFR3; Simple; p.Lys650Glu (c.1948A>G); ClinVar=VCV000016331; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6768; SMAD2; Simple; p.Leu87Arg (c.260T>G); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C3242; Plasma cell myeloma
DI   ORDO; Orphanet_29073; Multiple myeloma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1625 ! OPM-2
SX   Female
AG   56Y
CA   Cancer cell line
DT   Created: 14-12-15; Last updated: 05-10-23; Version: 12
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RX   PubMed=20555361; DOI=10.1038/leu.2010.137;
RA   Ri M., Iida S., Nakashima T., Miyazaki H., Mori F., Ito A.,
RA   Inagaki A., Kusumoto S., Ishida T., Komatsu H., Shiotsu Y., Ueda R.;
RT   "Bortezomib-resistant myeloma cell lines: a role for mutated PSMB5 in
RT   preventing the accumulation of unfolded proteins and fatal ER
RT   stress.";
RL   Leukemia 24:1506-1512(2010).
//