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Cellosaurus RPMI-8226/MR4 (CVCL_4V90)

[Text version]
Cell line name RPMI-8226/MR4
Synonyms RPMI 8226/MR4; 8226/MR4
Accession CVCL_4V90
Resource Identification Initiative To cite this cell line use: RPMI-8226/MR4 (RRID:CVCL_4V90)
Comments Population: African American.
Characteristics: Produces IgG lambda (from parent cell line).
Selected for resistance to: ChEBI; CHEBI:50729; Mitoxantrone.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Gene fusion; HGNC; 5722; IGKJ4 + HGNC; 5783; IGKV2-28; Name(s)=IGKV2-28-IGKJ4 (from parent cell line).
  • Gene fusion; HGNC; 5865; IGLJ3 + HGNC; 5888; IGLV2-14; Name(s)=IGLV2-14-IGLJ3 (from parent cell line).
  • Mutation; HGNC; 3236; EGFR; Simple; p.Thr751Ile (c.2252C>T); ClinVar=VCV000177773; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu285Lys (c.853G>A); ClinVar=VCV000420133; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 12033; TRAF3; Simple; p.Lys191Leufs*60; Zygosity=Unspecified (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0014 (RPMI-8226)
Children:
CVCL_0509 (RPMI-8226/MR20)
Sex of cell Male
Age at sampling 61Y
Category Cancer cell line
Publications

PubMed=10070958
Hazlehurst L.A., Foley N.E., Gleason-Guzman M.C., Hacker M.P., Cress A.E., Greenberger L.M., de Jong M.C., Dalton W.S.
Multiple mechanisms confer drug resistance to mitoxantrone in the human 8226 myeloma cell line.
Cancer Res. 59:1021-1028(1999)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4V90
Encyclopedic resources Wikidata; Q54951251
Entry history
Entry creation14-Dec-2015
Last entry update05-Oct-2023
Version number14