Cellosaurus RPMI-8226/MR4 (CVCL_4V90)

Cell line name RPMI-8226/MR4
Synonyms RPMI 8226/MR4; 8226/MR4
Accession CVCL_4V90
Resource Identification Initiative To cite this cell line use: RPMI-8226/MR4 (RRID:CVCL_4V90)
Comments Characteristics: Produces IgG lambda.
Selected for resistance to: ChEBI; CHEBI:50729; Mitoxantrone.
Sequence variation: Heterozygous for EGFR p.Thr751Ile (from parent cell line).
Sequence variation: Heterozygous for KRAS p.Gly12Ala (from parent cell line).
Sequence variation: Homozygous for TP53 p.Glu285Lys (from parent cell line).
Derived from sampling site: Peripheral blood.
Disease Plasma cell myeloma (NCIt: C3242)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0014 (RPMI-8226)
CVCL_0509 (RPMI-8226/MR20)
Sex of cell Male
Category Cancer cell line

Hazlehurst L.A., Foley N.E., Gleason-Guzman M.C., Hacker M.P., Cress A.E., Greenberger L.M., De Jong M.C., Dalton W.S.
Multiple mechanisms confer drug resistance to mitoxantrone in the human 8226 myeloma cell line.
Cancer Res. 59:1021-1028(1999)