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Cellosaurus MCF-7-EpiR (CVCL_4V96)

[Text version]

Cell line name MCF-7-EpiR
Accession CVCL_4V96
Resource Identification Initiative To cite this cell line use: MCF-7-EpiR (RRID:CVCL_4V96)
Comments Selected for resistance to: ChEBI; CHEBI:47898; 4'-epidoxorubicin (Epirubicin).
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line

PubMed=23514751; DOI=10.1093/carcin/bgt098
Khongkow M., Olmos Y., Gong C., Gomes A.R., Monteiro L.J., Yague E., Cavaco T.B., Khongkow P., Man E.P.S., Laohasinnarong S., Koo C.-Y., Harada-Shoji N., Tsang J.W.-H., Coombes R.C., Schwer B., Khoo U.-S., Lam E.W.-F.
SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer.
Carcinogenesis 34:1476-1486(2013)

Other Wikidata; Q54904331
Entry history
Entry creation14-Dec-2015
Last entry update02-Jul-2020
Version number7