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Cellosaurus MCF-7-TaxR (CVCL_4V97)

[Text version]
Cell line name MCF-7-TaxR
Accession CVCL_4V97
Resource Identification Initiative To cite this cell line use: MCF-7-TaxR (RRID:CVCL_4V97)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=23514751; DOI=10.1093/carcin/bgt098
Khongkow M., Olmos Y., Gong C., Gomes A.R., Monteiro L.J., Yague E., Cavaco T.B., Khongkow P., Man E.P.S., Laohasinnarong S., Koo C.-Y., Harada-Shoji N., Tsang J.W.-H., Coombes R.C., Schwer B., Khoo U.-S., Lam E.W.-F.
SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer.
Carcinogenesis 34:1476-1486(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4V97
Encyclopedic resources Wikidata; Q54904336
Entry history
Entry creation14-Dec-2015
Last entry update05-Oct-2023
Version number13