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Cellosaurus J82-NVB (CVCL_4V98)

[Text version]

Cell line name J82-NVB
Accession CVCL_4V98
Resource Identification Initiative To cite this cell line use: J82-NVB (RRID:CVCL_4V98)
Comments Selected for resistance to: ChEBI; CHEBI:480999; Vinorelbine (Navelbine; NVB).
Sequence variations Mutation; HGNC; 583; APC; Simple; p.Ser770Pro (c.2308T>C); ClinVar=VCV000140988; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro124Leu (c.371C>T); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 9588; PTEN; Simple; p.Asn212fs*1 (c.635_1212del578); Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 9884; RB1; Simple; c.2107-2A>G; ClinVar=VCV000013077; Zygosity=Homozygous; Note=Splice acceptor mutation (from parent cell line).
Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Glu271Lys (c.811G>A); ClinVar=VCV000406566; Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Lys320Asn (c.960G>C); Zygosity=Heterozygous (from parent cell line).
Disease Bladder carcinoma (NCIt: C4912)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0359 (J82)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=7981063; DOI=10.1038/bjc.1994.458
Debal V., Allam N., Morjani H., Millot J.M., Braguer D., Breillout F., Manfait M.
Characterisation of a navelbine-resistant bladder carcinoma cell line cross-resistant to taxoids.
Br. J. Cancer 70:1118-1125(1994)

Cross-references
Other Wikidata; Q54898492
Entry history
Entry creation14-Dec-2015
Last entry update20-May-2021
Version number10