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Cellosaurus Huh7S1 (CVCL_4W53)

[Text version]

Cell line name Huh7S1
Accession CVCL_4W53
Resource Identification Initiative To cite this cell line use: Huh7S1 (RRID:CVCL_4W53)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:50924; Sorafenib (Nexavar).
Sequence variations KDR p.Gln472His (c.1416A>T) (from parent cell line).
POLD3 p.Lys70Arg (c.209A>G) (from parent cell line).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
TP53 p.Tyr220Cys (c.659A>G) (ClinVar=VCV000127819) (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0336 (Huh-7)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line
Publications

PubMed=23111106; DOI=10.1016/j.canlet.2012.10.021
van Malenstein H., Dekervel J., Verslype C., Van Cutsem E., Windmolders P., Nevens F., van Pelt J.
Long-term exposure to sorafenib of liver cancer cells induces resistance with epithelial-to-mesenchymal transition, increased invasion and risk of rebound growth.
Cancer Lett. 329:74-83(2013)

Cross-references
Other Wikidata; Q54896862
Entry history
Entry creation14-Dec-2015
Last entry update02-Jul-2020
Version number6