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Cellosaurus POLK KO homo MSH- (CVCL_4W73)

[Text version]
Cell line name POLK KO homo MSH-
Synonyms Nalm-6-MSH-/TK+/-/POLK-/-
Accession CVCL_4W73
Resource Identification Initiative To cite this cell line use: POLK KO homo MSH- (RRID:CVCL_4W73)
Comments Population: Caucasian.
Knockout cell: Method=Homologous recombination; HGNC; 9183; POLK.
Knockout cell: Method=Homologous recombination; HGNC; 11830; TK1 (Note=1 of 2 alleles).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 50800; DUX4 + HGNC; 5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line).
  • Mutation; HGNC; 3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line).
Disease Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_UD96 (Nalm-6-TK+/-)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): JCRB

Markers:
AmelogeninX,Y
CSF1PO14
D5S81811,12
D7S8208,12
D13S3179,13
D16S53910,11
TH018,9
TPOX8,10
vWA15,16

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Publications

PubMed=24461735; DOI=10.1016/j.dnarep.2013.12.008
Sassa A., Suzuki T., Kanemaru Y., Niimi N., Fujimoto H., Katafuchi A., Gruz P., Yasui M., Gupta R.C., Johnson F., Ohta T., Honma M., Adachi N., Nohmi T.
In vivo evidence that phenylalanine 171 acts as a molecular brake for translesion DNA synthesis across benzo[a]pyrene DNA adducts by human DNA polymerase kappa.
DNA Repair 15:21-28(2014)

Cross-references
Cell line collections (Providers) JCRB; JCRB1514
Cell line databases/resources cancercelllines; CVCL_4W73
Encyclopedic resources Wikidata; Q54947730
Entry history
Entry creation14-Dec-2015
Last entry update30-Jan-2024
Version number14