Cellosaurus DU-145 R (CVCL_4Y36)

Cell line name DU-145 R
Accession CVCL_4Y36
Resource Identification Initiative To cite this cell line use: DU-145 R (RRID:CVCL_4Y36)
Comments Selected for resistance to: ChEBI; CHEBI:4672; Docetaxel anhydrous (Taxotere).
Sequence variation: Homozygous for CDKN2A p.Asp84Tyr (from parent cell line).
Sequence variation: Homozygous for RB1 p.Lys715Ter (from parent cell line).
Sequence variation: Homozygous for STK11 p.Lys178fs*86 (from parent cell line).
Sequence variation: Heterozygous for TP53 p.Val274Phe (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Derived from metastatic site: Brain.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0105 (DU145)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line

PubMed=21982118; DOI=10.1186/1476-4598-10-126
O'Neill A.J., Prencipe M., Dowling C., Fan Y., Mulrane L., Gallagher W.M., O'Connor D., O'Connor R., Devery A., Corcoran C., Rani S., O'Driscoll L., Fitzpatrick J.M., Watson R.W.
Characterisation and manipulation of docetaxel resistant prostate cancer cell lines.
Mol. Cancer 10:126-126(2011)