Cellosaurus H3122 CHR-A1 (CVCL_4Y37)

Cell line name H3122 CHR-A1
Synonyms H3122-CHR-A1
Accession CVCL_4Y37
Resource Identification Initiative To cite this cell line use: H3122 CHR-A1 (RRID:CVCL_4Y37)
Comments Selected for resistance to: ChEBI; CHEBI:62268; Alectinib (CH5424802; RO5424802; AF-802).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5160 (NCI-H3122)
Category Cancer cell line

PubMed=25228534; DOI=10.1158/1078-0432.CCR-14-1511
Katayama R., Friboulet L., Koike S., Lockerman E.L., Khan T.M., Gainor J.F., Iafrate A.J., Takeuchi K., Taiji M., Okuno Y., Fujita N., Engelman J.A., Shaw A.T.
Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib.
Clin. Cancer Res. 20:5686-5696(2014)

Polymorphism and mutation databases Cosmic; 2245572