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Cellosaurus H3122 CHR-A1 (CVCL_4Y37)

[Text version]

Cell line name H3122 CHR-A1
Synonyms H3122-CHR-A1
Accession CVCL_4Y37
Resource Identification Initiative To cite this cell line use: H3122 CHR-A1 (RRID:CVCL_4Y37)
Comments Selected for resistance to: ChEBI; CHEBI:62268; Alectinib (CH5424802; RO5424802; AF-802).
Sequence variations EML4-ALK gene fusion (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5160 (NCI-H3122)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line

PubMed=25228534; DOI=10.1158/1078-0432.CCR-14-1511
Katayama R., Friboulet L., Koike S., Lockerman E.L., Khan T.M., Gainor J.F., Iafrate A.J., Takeuchi K., Taiji M., Okuno Y., Fujita N., Engelman J.A., Shaw A.T.
Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib.
Clin. Cancer Res. 20:5686-5696(2014)

Other Wikidata; Q54872052
Polymorphism and mutation databases Cosmic; 2245572
Entry history
Entry creation14-Dec-2015
Last entry updated05-Jul-2019
Version number3