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Cellosaurus MDA-MB-231 50PACR (CVCL_4Y39)

[Text version]

Cell line name MDA-MB-231 50PACR
Accession CVCL_4Y39
Resource Identification Initiative To cite this cell line use: MDA-MB-231 50PACR (RRID:CVCL_4Y39)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol).
Sequence variations Heterozygous for BRAF p.Gly464Val (c.1391G>T) (ClinVar=VCV000040364) (from parent cell line).
Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for KRAS p.Gly13Asp (c.38G>A) (ClinVar=VCV000012580) (from parent cell line).
TERT c.228C>T (-124C>T); in promoter (from parent cell line).
Homozygous for TP53 p.Arg280Lys (c.839G>A) (ClinVar=VCV000376657) (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0062 (MDA-MB-231)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=25312014; DOI=10.1186/1471-2407-14-762
Kenicer J., Spears M., Lyttle N., Taylor K.J., Liao L., Cunningham C.A., Lambros M.B., MacKay A., Yao C., Reis-Filho J.S., Bartlett J.M.S.
Molecular characterisation of isogenic taxane resistant cell lines identify novel drivers of drug resistance.
BMC Cancer 14:762-762(2014)

Cross-references
Other Wikidata; Q54904581
Entry history
Entry creation14-Dec-2015
Last entry update02-Jul-2020
Version number9