ID   ZR75-1 25DOCR
AC   CVCL_4Y42
DR   Wikidata; Q54996129
RX   PubMed=25312014;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:4672; Docetaxel anhydrous (Taxotere).
CC   Sequence variation: Mutation; HGNC; 5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
CC   Derived from metastatic site: Ascites.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_0588 ! ZR-75-1
SX   Female
AG   63Y
CA   Cancer cell line
DT   Created: 14-12-15; Last updated: 23-09-21; Version: 8
//
RX   PubMed=25312014; DOI=10.1186/1471-2407-14-762;
RA   Kenicer J., Spears M., Lyttle N., Taylor K.J., Liao L.,
RA   Cunningham C.A., Lambros M.B., MacKay A., Yao C., Reis-Filho J.S.,
RA   Bartlett J.M.S.;
RT   "Molecular characterisation of isogenic taxane resistant cell lines
RT   identify novel drivers of drug resistance.";
RL   BMC Cancer 14:762.1-762.10(2014).
//