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Cellosaurus MCF-7/AdrVp (CVCL_4Y46)

[Text version]

Cell line name MCF-7/AdrVp
Synonyms MCF7/AdrVp; MCF-7-ADRVP; MCF-7 AdVp; MCF-7/AdrVp(100)
Accession CVCL_4Y46
Resource Identification Initiative To cite this cell line use: MCF-7/AdrVp (RRID:CVCL_4Y46)
Comments Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Selected for resistance to: ChEBI; CHEBI:9948; Verapamil (VPL).
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
CVCL_KS20 (MCF-7/AdVp3000)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line

Chen Y.-N., Mickley L.A., Schwartz A.M., Acton E.M., Hwang J.L., Fojo A.T.
Characterization of adriamycin-resistant human breast cancer cells which display overexpression of a novel resistance-related membrane protein.
J. Biol. Chem. 265:10073-10080(1990)

PubMed=7819048; DOI=10.1038/bjc.1995.11
Doyle L.A., Ross D.D., Sridhara R., Fojo A.T., Kaufmann S.H., Lee E.J., Schiffer C.A.
Expression of a 95 kDa membrane protein is associated with low daunorubicin accumulation in leukaemic blast cells.
Br. J. Cancer 71:52-58(1995)

Rabindran S.K., He H., Singh M., Brown E., Collins K.I., Annable T., Greenberger L.M.
Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C.
Cancer Res. 58:5850-5858(1998)

PubMed=14576842; DOI=10.1038/sj.onc.1206938
Doyle L.A., Ross D.D.
Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2).
Oncogene 22:7340-7358(2003)

Other Wikidata; Q54904351
Entry history
Entry creation14-Dec-2015
Last entry update02-Jul-2020
Version number7