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Cellosaurus MCF/MX (CVCL_4Y47)

[Text version]

Cell line name MCF/MX
Synonyms MCF-7/MX; MCF-7/mtxR
Accession CVCL_4Y47
Resource Identification Initiative To cite this cell line use: MCF/MX (RRID:CVCL_4Y47)
Comments Selected for resistance to: ChEBI; CHEBI:50729; Mitoxantrone.
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=1358431
Nakagawa M., Schneider E., Dixon K.H., Horton J.K., Kelley K., Morrow C., Cowan K.H.
Reduced intracellular drug accumulation in the absence of P-glycoprotein (mdr1) overexpression in mitoxantrone-resistant human MCF-7 breast cancer cells.
Cancer Res. 52:6175-6181(1992)

PubMed=7664272
Yang C.J., Horton J.K., Cowan K.H., Schneider E.
Cross-resistance to camptothecin analogues in a mitoxantrone-resistant human breast carcinoma cell line is not due to DNA topoisomerase I alterations.
Cancer Res. 55:4004-4009(1995)

PubMed=9865745
Rabindran S.K., He H., Singh M., Brown E., Collins K.I., Annable T., Greenberger L.M.
Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C.
Cancer Res. 58:5850-5858(1998)

PubMed=11559526
Honjo Y., Hrycyna C.A., Yan Q.-W., Medina-Perez W.Y., Robey R.W., van de Laar A., Litman T., Dean M., Bates S.E.
Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.
Cancer Res. 61:6635-6639(2001)

Cross-references
Other Wikidata; Q54904412
Entry history
Entry creation14-Dec-2015
Last entry update02-Jul-2020
Version number7