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Cellosaurus MCF/MX (CVCL_4Y47)

[Text version]

Cell line name MCF/MX
Synonyms MCF-7/MX; MCF-7/mtxR
Accession CVCL_4Y47
Resource Identification Initiative To cite this cell line use: MCF/MX (RRID:CVCL_4Y47)
Comments Selected for resistance to: ChEBI; CHEBI:50729; Mitoxantrone.
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line

Nakagawa M., Schneider E., Dixon K.H., Horton J.K., Kelley K., Morrow C., Cowan K.H.
Reduced intracellular drug accumulation in the absence of P-glycoprotein (mdr1) overexpression in mitoxantrone-resistant human MCF-7 breast cancer cells.
Cancer Res. 52:6175-6181(1992)

Yang C.J., Horton J.K., Cowan K.H., Schneider E.
Cross-resistance to camptothecin analogues in a mitoxantrone-resistant human breast carcinoma cell line is not due to DNA topoisomerase I alterations.
Cancer Res. 55:4004-4009(1995)

Rabindran S.K., He H., Singh M., Brown E., Collins K.I., Annable T., Greenberger L.M.
Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C.
Cancer Res. 58:5850-5858(1998)

Honjo Y., Hrycyna C.A., Yan Q.-W., Medina-Perez W.Y., Robey R.W., van de Laar A., Litman T., Dean M., Bates S.E.
Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.
Cancer Res. 61:6635-6639(2001)

Other Wikidata; Q54904412
Entry history
Entry creation14-Dec-2015
Last entry update02-Jul-2020
Version number7