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Cellosaurus MCF-7:2A (CVCL_4Y53)

[Text version]
Cell line name MCF-7:2A
Accession CVCL_4Y53
Resource Identification Initiative To cite this cell line use: MCF-7:2A (RRID:CVCL_4Y53)
Comments Population: Caucasian.
Caution: There is confusion in the literature between estrogen-independent MCF-7:2A (Cellosaurus=CVCL_4Y53), L-mimosine-resistant MCF-7/2a (Cellosaurus=CVCL_0412) and EREwtcluc transfected MCF-7-2a (Cellosaurus=CVCL_4Y54).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=7780972
Pink J.J., Jiang S.-Y., Fritsch M., Jordan V.C.
An estrogen-independent MCF-7 breast cancer cell line which contains a novel 80-kilodalton estrogen receptor-related protein.
Cancer Res. 55:2583-2590(1995)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4Y53
Encyclopedic resources Wikidata; Q54904399
Entry history
Entry creation14-Dec-2015
Last entry update05-Oct-2023
Version number14