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Cellosaurus MCF-7-2a (CVCL_4Y54)

[Text version]
Cell line name MCF-7-2a
Synonyms MCF-7/2a; MCF7-2A; MCF7-2a; MCF-7.2A
Accession CVCL_4Y54
Resource Identification Initiative To cite this cell line use: MCF-7-2a (RRID:CVCL_4Y54)
Comments Population: Caucasian.
Transfected with: UniProtKB; P08659; Firefly luciferase.
Caution: There is confusion in the literature between estrogen-independent MCF-7:2A (Cellosaurus=CVCL_4Y53), L-mimosine-resistant MCF-7/2a (Cellosaurus=CVCL_0412) and EREwtcluc transfected MCF-7-2a (Cellosaurus=CVCL_4Y54).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=8138561; DOI=10.1007/BF01247461
Meyer T., Koop R., von Angerer E., Schonenberger H., Holler E.
A rapid luciferase transfection assay for transcription activation effects and stability control of estrogenic drugs in cell cultures.
J. Cancer Res. Clin. Oncol. 120:359-364(1994)

PubMed=8903422; DOI=10.1016/0960-0760(96)00054-4
Hafner F., Holler E., von Angerer E.
Effect of growth factors on estrogen receptor mediated gene expression.
J. Steroid Biochem. Mol. Biol. 58:385-393(1996)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4Y54
Chemistry resources ChEMBL-Cells; CHEMBL3307366
ChEMBL-Targets; CHEMBL614323
PubChem_Cell_line; CVCL_4Y54
Encyclopedic resources Wikidata; Q54904328
Entry history
Entry creation14-Dec-2015
Last entry update05-Oct-2023
Version number15