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Cellosaurus MCF-7-2a (CVCL_4Y54)

[Text version]

Cell line name MCF-7-2a
Synonyms MCF-7/2a; MCF7-2A; MCF7-2a; MCF-7.2A
Accession CVCL_4Y54
Resource Identification Initiative To cite this cell line use: MCF-7-2a (RRID:CVCL_4Y54)
Comments Transfected with: UniProtKB; P08659; Firefly luciferase.
Caution: There is confusion in the literature between estrogen-independent MCF-7:2A (CVCL_4Y53), L-mimosine-resistant MCF-7/2a (CVCL_0412) and EREwtcluc transfected MCF-7-2a (CVCL_4Y54).
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line

PubMed=8138561; DOI=10.1007/BF01247461
Meyer T., Koop R., von Angerer E., Schonenberger H., Holler E.
A rapid luciferase transfection assay for transcription activation effects and stability control of estrogenic drugs in cell cultures.
J. Cancer Res. Clin. Oncol. 120:359-364(1994)

PubMed=8903422; DOI=10.1016/0960-0760(96)00054-4
Hafner F., Holler E., von Angerer E.
Effect of growth factors on estrogen receptor mediated gene expression.
J. Steroid Biochem. Mol. Biol. 58:385-393(1996)

Chemistry resources ChEMBL-Cells; CHEMBL3307366
ChEMBL-Targets; CHEMBL614323
Other Wikidata; Q54904328
Entry history
Entry creation14-Dec-2015
Last entry update02-Jul-2020
Version number8