ID   MCF-7-2a
AC   CVCL_4Y54
SY   MCF-7/2a; MCF7-2A; MCF7-2a; MCF-7.2A
DR   cancercelllines; CVCL_4Y54
DR   ChEMBL-Cells; CHEMBL3307366
DR   ChEMBL-Targets; CHEMBL614323
DR   PubChem_Cell_line; CVCL_4Y54
DR   Wikidata; Q54904328
RX   PubMed=8138561;
RX   PubMed=8903422;
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: UniProtKB; P08659; Firefly luciferase.
CC   Caution: There is confusion in the literature between estrogen-independent MCF-7:2A (Cellosaurus=CVCL_4Y53), L-mimosine-resistant MCF-7/2a (Cellosaurus=CVCL_0412) and EREwtcluc transfected MCF-7-2a (Cellosaurus=CVCL_4Y54).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 14-12-15; Last updated: 05-10-23; Version: 15
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RX   PubMed=8138561; DOI=10.1007/BF01247461;
RA   Meyer T., Koop R., von Angerer E., Schonenberger H., Holler E.;
RT   "A rapid luciferase transfection assay for transcription activation
RT   effects and stability control of estrogenic drugs in cell cultures.";
RL   J. Cancer Res. Clin. Oncol. 120:359-364(1994).
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RX   PubMed=8903422; DOI=10.1016/0960-0760(96)00054-4;
RA   Hafner F., Holler E., von Angerer E.;
RT   "Effect of growth factors on estrogen receptor mediated gene
RT   expression.";
RL   J. Steroid Biochem. Mol. Biol. 58:385-393(1996).
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