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Cellosaurus CHOC 400 (CVCL_4Y55)

[Text version]
Cell line name CHOC 400
Synonyms CHOC400; CHO C400
Accession CVCL_4Y55
Resource Identification Initiative To cite this cell line use: CHOC 400 (RRID:CVCL_4Y55)
Comments Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_0213 (CHO)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=6273843; DOI=10.1073/pnas.78.10.6043
Milbrandt J.D., Heintz N.H., White W.C., Rothman S.M., Hamlin J.L.
Methotrexate-resistant Chinese hamster ovary cells have amplified a 135-kilobase-pair region that includes the dihydrofolate reductase gene.
Proc. Natl. Acad. Sci. U.S.A. 78:6043-6047(1981)

PubMed=2841578; DOI=10.1128/mcb.8.6.2316-2327.1988
Ma C., Looney J.E., Leu T.-H., Hamlin J.L.
Organization and genesis of dihydrofolate reductase amplicons in the genome of a methotrexate-resistant Chinese hamster ovary cell line.
Mol. Cell. Biol. 8:2316-2327(1988)

Cross-references
Encyclopedic resources Wikidata; Q54813207
Entry history
Entry creation14-Dec-2015
Last entry update30-Jan-2024
Version number7