ID   CHOC 400
AC   CVCL_4Y55
SY   CHOC400; CHO C400
DR   Wikidata; Q54813207
RX   PubMed=2841578;
RX   PubMed=6273843;
CC   Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_0213 ! CHO
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 14-12-15; Last updated: 30-01-24; Version: 7
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RX   PubMed=2841578; DOI=10.1128/mcb.8.6.2316-2327.1988;
RA   Ma C., Looney J.E., Leu T.-H., Hamlin J.L.;
RT   "Organization and genesis of dihydrofolate reductase amplicons in the
RT   genome of a methotrexate-resistant Chinese hamster ovary cell line.";
RL   Mol. Cell. Biol. 8:2316-2327(1988).
//
RX   PubMed=6273843; DOI=10.1073/pnas.78.10.6043;
RA   Milbrandt J.D., Heintz N.H., White W.C., Rothman S.M., Hamlin J.L.;
RT   "Methotrexate-resistant Chinese hamster ovary cells have amplified a
RT   135-kilobase-pair region that includes the dihydrofolate reductase
RT   gene.";
RL   Proc. Natl. Acad. Sci. U.S.A. 78:6043-6047(1981).
//