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Cellosaurus MVLN (CVCL_4Y56)

[Text version]

Cell line name MVLN
Synonyms MVLN 15-C7; MVLN-15-C7; MCF-7 Vit Luc Neo
Accession CVCL_4Y56
Resource Identification Initiative To cite this cell line use: MVLN (RRID:CVCL_4Y56)
Comments Biotechnology: Used in a bioluminescent bioassay to quantitatively measure estrogenic compounds.
Characteristics: The luciferase gene is under the control of an estrogen-responsive element from the Xenopus vitellogenin A2 gene.
Doubling time: 0.8 +- 0.1 day (PubMed=7954415).
Transfected with: UniProtKB; P08659; Firefly luciferase.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (ClinVar=VCV000013655) (from parent cell line).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line

Pons M., Gagne D., Nicolas J.-C., Mehtali M.
A new cellular model of response to estrogens: a bioluminescent test to characterize (anti) estrogen molecules.
BioTechniques 9:450-459(1990)

PubMed=9831484; DOI=10.1016/0960-0760(93)90225-L
Demirpence E., Duchesne M.-J., Badia E., Gagne D., Pons M.
MVLN cells: a bioluminescent MCF-7-derived cell line to study the modulation of estrogenic activity.
J. Steroid Biochem. Mol. Biol. 46:355-364(1993)

Badia E., Duchesne M.-J., Fournier-Bidoz S., Simar-Blanchet A.-E., Terouanne B., Nicolas J.-C., Pons M.
Hydroxytamoxifen induces a rapid and irreversible inactivation of an estrogenic response in an MCF-7-derived cell line.
Cancer Res. 54:5860-5866(1994)

Chemistry resources ChEMBL-Cells; CHEMBL3307321
ChEMBL-Targets; CHEMBL614185
Other Wikidata; Q54907119
Entry history
Entry creation14-Dec-2015
Last entry update02-Jul-2020
Version number9