ID   MVLN
AC   CVCL_4Y56
SY   MVLN 15-C7; MVLN-15-C7; MCF-7 Vit Luc Neo
DR   cancercelllines; CVCL_4Y56
DR   ChEMBL-Cells; CHEMBL3307321
DR   ChEMBL-Targets; CHEMBL614185
DR   PubChem_Cell_line; CVCL_4Y56
DR   Wikidata; Q54907119
RX   PubMed=2257144;
RX   PubMed=7954415;
RX   PubMed=9831484;
CC   Population: Caucasian.
CC   Biotechnology: Used in a bioluminescent bioassay to quantitatively measure estrogenic compounds.
CC   Characteristics: The luciferase reporter gene is under the control of an estrogen-responsive element from the Xenopus vitellogenin A2 gene.
CC   Doubling time: 0.8 +- 0.1 day (PubMed=7954415).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: UniProtKB; P08659; Firefly luciferase.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 14-12-15; Last updated: 05-10-23; Version: 16
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RX   PubMed=2257144;
RA   Pons M., Gagne D., Nicolas J.-C., Mehtali M.;
RT   "A new cellular model of response to estrogens: a bioluminescent test
RT   to characterize (anti) estrogen molecules.";
RL   BioTechniques 9:450-459(1990).
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RX   PubMed=7954415;
RA   Badia E., Duchesne M.-J., Fournier-Bidoz S., Simar-Blanchet A.-E.,
RA   Terouanne B., Nicolas J.-C., Pons M.;
RT   "Hydroxytamoxifen induces a rapid and irreversible inactivation of an
RT   estrogenic response in an MCF-7-derived cell line.";
RL   Cancer Res. 54:5860-5866(1994).
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RX   PubMed=9831484; DOI=10.1016/0960-0760(93)90225-L;
RA   Demirpence E., Duchesne M.-J., Badia E., Gagne D., Pons M.;
RT   "MVLN cells: a bioluminescent MCF-7-derived cell line to study the
RT   modulation of estrogenic activity.";
RL   J. Steroid Biochem. Mol. Biol. 46:355-364(1993).
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