| Cell line name |
IGROV-1/APL |
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| Accession |
CVCL_4Y61 |
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| Resource Identification Initiative |
To cite this cell line use: IGROV-1/APL (RRID:CVCL_4Y61) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:90205; Plitidepsin (Dehydrodidemnin B; Aplidin).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992. |
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| Sequence variations |
- Mutation; HGNC; 1100; BRCA1; Simple; p.Lys654Serfs*47 (c.1961delA); ClinVar=VCV000037438; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 1101; BRCA2; Simple; p.Lys1108Argfs*11 (c.3323delA) (p.Gln1107fs) (c.3320delA); ClinVar=VCV000225716; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Arg38Cys (c.112C>T); ClinVar=VCV000376493; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Ter1069TrpinsLysAspAsn (c.3207A>G); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9588; PTEN; Simple; p.Thr319fs*1 (c.955_958delACTT) (p.VL317fs) (V317fs*3); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9884; RB1; Simple; p.Val654Cysfs*4 (c.1959delA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6770; SMAD4; Simple; p.Gly231Alafs*10 (c.692delG); ClinVar=VCV001756201; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6770; SMAD4; Simple; p.Leu495Pro (c.1484T>C); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Ser90Leufs*59 (c.267dupC) (c.267_268insC); ClinVar=VCV000634762; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Tyr126Cys (c.377A>G); ClinVar=VCV000458541; Zygosity=Heterozygous (from parent cell line).
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| Disease |
Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1304 (IGROV-1) |
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| Sex of cell |
Female |
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| Age at sampling |
47Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=16258264; DOI=10.4161/cbt.4.12.2157
Tognon G., Bernasconi S., Celli N., Faircloth G.T., Cuevas C., Jimeno J.M., Erba E., D'Incalci M.
Induction of resistance to Aplidin in a human ovarian cancer cell line related to MDR expression.
Cancer Biol. Ther. 4:1325-1330(2005) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_4Y61
|
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| Encyclopedic resources |
Wikidata; Q54897384
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| Entry history |
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| Entry creation | 14-Dec-2015 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 16 |
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