Cellosaurus IGROV-1/APL (CVCL_4Y61)

Cell line name IGROV-1/APL
Accession CVCL_4Y61
Resource Identification Initiative To cite this cell line use: IGROV-1/APL (RRID:CVCL_4Y61)
Comments Selected for resistance to: ChEBI; CHEBI:90205; Plitidepsin (Dehydrodidemnin B; Aplidin).
Sequence variation: Heterozygous for BRCA1 p.Lys654fs*47 (from parent cell line).
Sequence variation: Heterozygous for SMAD4 p.Gly231fs*10 (from parent cell line).
Sequence variation: Heterozygous for PTEN p.Thr319fs*1 (from parent cell line).
Sequence variation: Heterozygous for TP53 p.Tyr126Cys (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1304 (IGROV-1)
Sex of cell Female
Category Cancer cell line
Publications

PubMed=16258264; DOI=10.4161/cbt.4.12.2157
Tognon G., Bernasconi S., Celli N., Faircloth G.T., Cuevas C., Jimeno J., Erba E., D'Incalci M.
Induction of resistance to Aplidin in a human ovarian cancer cell line related to MDR expression.
Cancer Biol. Ther. 4:1325-1330(2005)