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Cellosaurus TC-248 (CVCL_4Z35)

[Text version]
Cell line name TC-248
Synonyms TC248
Accession CVCL_4Z35
Resource Identification Initiative To cite this cell line use: TC-248 (RRID:CVCL_4Z35)
Comments Part of: MD Anderson Cell Lines Project.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis by RNAseq.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=25010205).
  • Gene fusion; HGNC; 3508; EWSR1 + HGNC; 3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 1 fusion (Ex7/Ex6) (PubMed=25010205).
  • Mutation; HGNC; 11998; TP53; Simple; p.Asp259Tyr (c.775G>T); ClinVar=VCV000634680; Zygosity=Unspecified (PubMed=25010205).
Disease Ewing sarcoma/peripheral primitive neuroectodermal tumor (NCIt: C27291)
Bone sarcoma (ORDO: Orphanet_223727)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Category Cancer cell line
STR profile Source(s): PubMed=25010205

Markers:
AmelogeninX
CSF1PO10,11
D2S133817
D3S135815
D5S81812,13
D7S8208,10
D8S117910,14
D13S31711
D16S5399,12
D18S5116,17
D19S43314,15
D21S1129,30
FGA19,20.2
TH017,8
TPOX11
vWA17,18

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=25010205; DOI=10.1371/journal.pgen.1004475
Brohl A.S., Solomon D.A., Chang W., Wang J.-J., Song Y., Sindiri S., Patidar R., Hurd L., Chen L., Shern J.F., Liao H.-L., Wen X.-Y., Gerard J., Kim J.-S., Lopez Guerrero J.A., Machado I., Wai D.H., Picci P., Triche T.J., Horvai A.E., Miettinen M.M., Wei J.S., Catchpoole D., Llombart-Bosch A., Waldman T., Khan J.
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
PLoS Genet. 10:E1004475-E1004475(2014)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4Z35
Encyclopedic resources Wikidata; Q54971804
Polymorphism and mutation databases Cosmic; 2228241
Entry history
Entry creation14-Dec-2015
Last entry update05-Oct-2023
Version number11