Home  |  Contact

Cellosaurus UKE-1/TGR (CVCL_4Z62)

[Text version]
Cell line name UKE-1/TGR
Accession CVCL_4Z62
Resource Identification Initiative To cite this cell line use: UKE-1/TGR (RRID:CVCL_4Z62)
Comments Selected for resistance to: ChEBI; CHEBI:90304; TG101209 (N-(tert-butyl)-3-((5-methyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)benzenesulfonamide).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Mutation; HGNC; 6192; JAK2; Simple; p.Val617Phe (c.1849G>T); ClinVar=VCV000014662; Zygosity=Homozygous (from parent cell line).
Disease Essential thrombocythemia (NCIt: C3407)
Essential thrombocythemia (ORDO: Orphanet_3318)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0104 (UKE-1)
Sex of cell Female
Age at sampling 59Y
Category Cancer cell line
Publications

PubMed=21976548; DOI=10.1158/1078-0432.CCR-11-1541
Fiskus W., Verstovsek S., Manshouri T., Rao R., Balusu R., Venkannagari S., Nalabothula N., Ha K., Smith J.E., Hembruff S.L., Abhyankar S., McGuirk J.P., Bhalla K.N.
Heat shock protein 90 inhibitor is synergistic with JAK2 inhibitor and overcomes resistance to JAK2-TKI in human myeloproliferative neoplasm cells.
Clin. Cancer Res. 17:7347-7358(2011)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4Z62
Encyclopedic resources Wikidata; Q54990276
Entry history
Entry creation14-Dec-2015
Last entry update05-Oct-2023
Version number12