Cellosaurus UKE-1/TGR (CVCL_4Z62)

Cell line name UKE-1/TGR
Accession CVCL_4Z62
Resource Identification Initiative To cite this cell line use: UKE-1/TGR (RRID:CVCL_4Z62)
Comments Selected for resistance to: ChEBI; CHEBI:90304; TG101209 (N-(tert-butyl)-3-((5-methyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)benzenesulfonamide).
Derived from sampling site: Peripheral blood.
Sequence variations Homozygous for JAK2 p.Val617Phe (c.1849G>T) (from parent cell line).
Disease Essential thrombocythemia (NCIt: C3407)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0104 (UKE-1)
Sex of cell Female
Age at sampling 59Y
Category Cancer cell line

PubMed=21976548; DOI=10.1158/1078-0432.CCR-11-1541
Fiskus W., Verstovsek S., Manshouri T., Rao R., Balusu R., Venkannagari S., Rao N.N., Ha K., Smith J.E., Hembruff S.L., Abhyankar S., McGuirk J., Bhalla K.N.
Heat shock protein 90 inhibitor is synergistic with JAK2 inhibitor and overcomes resistance to JAK2-TKI in human myeloproliferative neoplasm cells.
Clin. Cancer Res. 17:7347-7358(2011)

Other Wikidata; Q54990276