ID   SNU-1033
AC   CVCL_5002
SY   SNU1033
DR   ArrayExpress; E-MTAB-2770
DR   BioSample; SAMN10987752
DR   cancercelllines; CVCL_5002
DR   Cell_Model_Passport; SIDM00192
DR   ColonAtlas; SNU1033
DR   Cosmic; 738855
DR   Cosmic; 2612379
DR   Cosmic; 2651858
DR   DepMap; ACH-000286
DR   GEO; GSM1448078
DR   IARC_TP53; 10837
DR   KCLB; 01033
DR   LiGeA; CCLE_623
DR   PharmacoDB; SNU1033_1433_2019
DR   Wikidata; Q54955088
RX   PubMed=10362137;
RX   PubMed=10674020;
RX   PubMed=19956504;
RX   PubMed=25926053;
RX   PubMed=26589293;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: Seoul National University (SNU) cell line collection.
CC   Population: Korean.
CC   Doubling time: 42 hours (PubMed=10362137).
CC   HLA typing: A*24:02,24:02; B*40:01,51:01; C*15:02,15:02 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (PubMed=10674020; PubMed=25926053).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (PubMed=10362137; DepMap).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Pro190Leu (c.569C>T); ClinVar=VCV000418517; Zygosity=Homozygous (PubMed=10362137; DepMap).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=18.67%; Native American=0%; East Asian, North=56.8%; East Asian, South=0%; South Asian=0%; European, North=0%; European, South=24.53% (PubMed=30894373).
CC   Derived from site: In situ; Rectum; UBERON=UBERON_0001052.
ST   Source(s): Genomics_Center_BCF_Technion; KCLB; PubMed=25926053
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D10S1248: 13,15
ST   D12S391: 18,21
ST   D13S317: 10
ST   D16S539: 9
ST   D18S51: 13
ST   D19S433: 13,14
ST   D1S1656: 13
ST   D21S11: 29,30
ST   D22S1045: 17
ST   D2S1338: 18,26
ST   D2S441: 10,12
ST   D3S1358: 14,17 (KCLB)
ST   D3S1358: 17 (Genomics_Center_BCF_Technion)
ST   D5S818: 13
ST   D7S820: 11,12 (Genomics_Center_BCF_Technion; PubMed=25926053)
ST   D7S820: 12 (KCLB)
ST   D8S1179: 12,13
ST   FGA: 23
ST   Penta D: 11,12
ST   Penta E: 11
ST   TH01: 9
ST   TPOX: 11
ST   vWA: 17,19
DI   NCIt; C9383; Rectal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   45Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 27
//
RX   PubMed=10362137; DOI=10.1002/(SICI)1097-0215(19990611)81:6<902::AID-IJC11>3.0.CO;2-T;
RA   Oh J.H., Ku J.-L., Yoon K.-A., Kwon H.-J., Kim W.-H., Park H.-S.,
RA   Yeo K.-S., Song S.-Y., Chung J.-K., Park J.-G.;
RT   "Establishment and characterization of 12 human colorectal-carcinoma
RT   cell lines.";
RL   Int. J. Cancer 81:902-910(1999).
//
RX   PubMed=10674020; DOI=10.1016/S0959-8049(99)00206-3;
RA   Ku J.-L., Yoon K.-A., Kim D.-Y., Park J.-G.;
RT   "Mutations in hMSH6 alone are not sufficient to cause the
RT   microsatellite instability in colorectal cancer cell lines.";
RL   Eur. J. Cancer 35:1724-1729(1999).
//
RX   PubMed=19956504; DOI=10.4143/crt.2005.37.1.1;
RA   Ku J.-L., Park J.-G.;
RT   "Biology of SNU cell lines.";
RL   Cancer Res. Treat. 37:1-19(2005).
//
RX   PubMed=25926053; DOI=10.1038/ncomms8002;
RA   Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G.,
RA   Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S.,
RA   Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M.,
RA   Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.;
RT   "The molecular landscape of colorectal cancer cell lines unveils
RT   clinically actionable kinase targets.";
RL   Nat. Commun. 6:7002.1-7002.10(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//