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Cellosaurus SNU-46 (CVCL_5063)

[Text version]

Cell line name SNU-46
Synonyms SNU46
Accession CVCL_5063
Resource Identification Initiative To cite this cell line use: SNU-46 (RRID:CVCL_5063)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: Seoul National University (SNU) cell line collection.
Doubling time: 36 hours (PubMed=10369293).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Homozygous for CDKN2A p.Pro114His (c.341C>A) (PubMed=10369293; CCLE).
Homozygous for TP53 p.Gly245Cys (c.733G>T) (PubMed=10369293; CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.74
Native American0
East Asian, North68.94
East Asian, South24.69
South Asian0
European, North0
European, South4.64
Disease Laryngeal squamous cell carcinoma (NCIt: C4044)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 65Y
Category Cancer cell line
STR profile Source(s): KCLB

Markers:
AmelogeninX
CSF1PO10,12
D3S135815
D5S81811
D7S82010,11
D13S31711
FGA21,24
TH019
TPOX8,11
vWA15,16

Run an STR similarity search on this cell line
Publications

CLPUB00001
Kim K.-H., Chung P.-S., Park H.-M., Rhee C.-S., Park J.-G.
Establishment and characterization of cell lines derived from squamous cell carcinoma of the head and neck.
Korean J. Head Neck Oncol. 12:181-187(1996)

PubMed=10369293; DOI=10.1097/00005537-199906000-00025
Ku J.-L., Kim W.-H., Lee J.-H., Park H.-S., Kim K.-H., Sung M.-W., Park J.-G.
Establishment and characterization of human laryngeal squamous cell carcinoma cell lines.
Laryngoscope 109:976-982(1999)

PubMed=19956504; DOI=10.4143/crt.2005.37.1.1
Ku J.-L., Park J.-G.
Biology of SNU cell lines.
Cancer Res. Treat. 37:1-19(2005)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections KCLB; 00046
Cell line databases/resources CCLE; SNU46_UPPER_AERODIGESTIVE_TRACT
Cell_Model_Passport; SIDM01448
DepMap; ACH-000500
Ontologies BTO; BTO:0005927
Biological sample resources BioSample; SAMN10988080
Chemistry resources PharmacoDB; SNU46_1463_2019
Gene expression databases GEO; GSM887629
GEO; GSM888714
Other Wikidata; Q54955202
Polymorphism and mutation databases Cosmic; 934173
IARC_TP53; 11322
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number17