ID   SNU-46
AC   CVCL_5063
SY   SNU46
DR   BTO; BTO:0005927
DR   BioSample; SAMN10988080
DR   CCLE; SNU46_UPPER_AERODIGESTIVE_TRACT
DR   Cell_Model_Passport; SIDM01448
DR   Cosmic; 934173
DR   DepMap; ACH-000500
DR   GEO; GSM887629
DR   GEO; GSM888714
DR   IARC_TP53; 11322
DR   KCLB; 00046
DR   PharmacoDB; SNU46_1463_2019
DR   Progenetix; CVCL_5063
DR   Wikidata; Q54955202
RX   CelloPub=CLPUB00001;
RX   PubMed=10369293;
RX   PubMed=19956504;
RX   PubMed=22460905;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Part of: Seoul National University (SNU) cell line collection.
CC   Population: Korean.
CC   Doubling time: 36 hours (PubMed=10369293).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Pro114His (c.341C>A) (p.Ala128Ala, c.384C>A); ClinVar=VCV000376383; Zygosity=Homozygous (PubMed=10369293; CCLE).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gly245Cys (c.733G>T); ClinVar=VCV000012349; Zygosity=Homozygous (PubMed=10369293; CCLE).
CC   Omics: Deep exome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=1.74%; Native American=0%; East Asian, North=68.94%; East Asian, South=24.69%; South Asian=0%; European, North=0%; European, South=4.64% (PubMed=30894373).
CC   Derived from sampling site: Larynx.
ST   Source(s): KCLB
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 11
ST   D3S1358: 15
ST   D5S818: 11
ST   D7S820: 10,11
ST   FGA: 21,24
ST   TH01: 9
ST   TPOX: 8,11
ST   vWA: 15,16
DI   NCIt; C4044; Laryngeal squamous cell carcinoma
DI   ORDO; Orphanet_494550; Squamous cell carcinoma of the larynx
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Male
AG   65Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 20-05-21; Version: 22
//
RX   CelloPub=CLPUB00001;
RA   Kim K.-H., Chung P.-S., Park H.-M., Rhee C.-S., Park J.-G.;
RT   "Establishment and characterization of cell lines derived from
RT   squamous cell carcinoma of the head and neck.";
RL   Korean J. Head Neck Oncol. 12:181-187(1996).
//
RX   PubMed=10369293; DOI=10.1097/00005537-199906000-00025;
RA   Ku J.-L., Kim W.-H., Lee J.-H., Park H.-S., Kim K.-H., Sung M.-W.,
RA   Park J.-G.;
RT   "Establishment and characterization of human laryngeal squamous cell
RT   carcinoma cell lines.";
RL   Laryngoscope 109:976-982(1999).
//
RX   PubMed=19956504; DOI=10.4143/crt.2005.37.1.1;
RA   Ku J.-L., Park J.-G.;
RT   "Biology of SNU cell lines.";
RL   Cancer Res. Treat. 37:1-19(2005).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//