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Cellosaurus SNU-478 (CVCL_5065)

[Text version]

Cell line name SNU-478
Synonyms SNU478; NCI-SNU-478
Accession CVCL_5065
Resource Identification Initiative To cite this cell line use: SNU-478 (RRID:CVCL_5065)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: Seoul National University (SNU) cell line collection.
Part of: TCGA-110-CL cell line panel.
Doubling time: 52 hours (PubMed=12107841).
Microsatellite instability: Stable (MSS) (PubMed=12107841).
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Homozygous for TP53 p.Gly266fs*4 (c.797_801delGACGG) (PubMed=12107841; CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.85
East Asian, North60.73
East Asian, South37.41
South Asian0
European, North0
European, South1.02
Disease Ampulla of Vater adenocarcinoma (NCIt: C6650)
Carcinoma of the ampulla of Vater (ORDO: Orphanet_300557)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): KCLB

Markers:
AmelogeninX
CSF1PO10,12
D3S135816,17
D5S8189,12
D7S8208,11
D13S3179,11
FGA24
TH017
TPOX10,11
vWA15,16

Run an STR similarity search on this cell line
Publications

PubMed=12107841; DOI=10.1038/sj.bjc.6600440
Ku J.-L., Yoon K.-A., Kim I.-J., Kim W.-H., Jang J.-Y., Suh K.-S., Kim S.-W., Park Y.-H., Hwang J.-H., Yoon Y.-B., Park J.-G.
Establishment and characterisation of six human biliary tract cancer cell lines.
Br. J. Cancer 87:187-193(2002)

PubMed=19956504; DOI=10.4143/crt.2005.37.1.1
Ku J.-L., Park J.-G.
Biology of SNU cell lines.
Cancer Res. Treat. 37:1-19(2005)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

CLPUB00275
Zach S., Birgin E., Ruckert F.
Primary cholangiocellular carcinoma cell lines.
J. Stem Cell Res. Transplant. 2:1013-1013(2015)

PubMed=26951071; DOI=10.1186/s12885-016-2193-5
Lai Z.W., Bolm L., Fuellgraf H., Biniossek M.L., Makowiec F., Hopt U.T., Werner M., Keck T., Bausch D., Sorio C., Scarpa A., Schilling O., Bronsert P., Wellner U.F.
Characterization of various cell lines from different ampullary cancer subtypes and cancer associated fibroblast-mediated responses.
BMC Cancer 16:195-195(2016)

PubMed=27231123; DOI=10.1158/2159-8290.CD-15-1442
Saha S.K., Gordan J.D., Kleinstiver B.P., Vu P., Najem M.S., Yeo J.-C., Shi L., Kato Y., Levin R.S., Webber J.T., Damon L.J., Egan R.K., Greninger P., McDermott U., Garnett M.J., Jenkins R.L., Rieger-Christ K.M., Sullivan T.B., Hezel A.F., Liss A.S., Mizukami Y., Goyal L., Ferrone C.R., Zhu A.X., Joung J.K., Shokat K.M., Benes C.H., Bardeesy N.
Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC dependence in intrahepatic cholangiocarcinoma.
Cancer Discov. 6:727-739(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31395879; DOI=10.1038/s41467-019-11415-2
Yu K., Chen B., Aran D., Charalel J., Yau C., Wolf D.M., van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
Nat. Commun. 10:3574-3574(2019)

Cross-references
Cell line collections KCLB; 00478
Cell line databases/resources CCLE; SNU478_BILIARY_TRACT
Cell_Model_Passport; SIDM00160
DepMap; ACH-000377
Biological sample resources BioSample; SAMN10988084
Chemistry resources PharmacoDB; SNU478_1466_2019
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887631
GEO; GSM888716
Other Wikidata; Q54955205
Polymorphism and mutation databases Cosmic; 738871
Cosmic; 2674053
IARC_TP53; 17160
LiGeA; CCLE_048
Proteomic databases PRIDE; PXD002657
Entry history
Entry creation04-Apr-2012
Last entry update12-Mar-2020
Version number21