Cellosaurus SNU-668 (CVCL_5081)

Cell line name SNU-668
Synonyms SNU668; NCI-SNU-668
Accession CVCL_5081
Resource Identification Initiative To cite this cell line use: SNU-668 (RRID:CVCL_5081)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: Seoul National University (SNU) cell line collection.
Sequence variation: KRAS p.Gln61Lys (PubMed=9033653).
Sequence variation: Homozygous for TP53 p.Ser251Asn (PubMed=9033653).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Signet ring cell gastric adenocarcinoma (NCIt: C5250)
Derived from metastatic site: Ascites.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_L049 (SNU-668-5FU); CVCL_L050 (SNU-668-CIS); CVCL_L051 (SNU-668-DOX)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): KCLB; PubMed=25877200

Markers:
AmelogeninX
CSF1PO12
D13S3178
D16S53911,12
D18S5113
D21S1130
D3S135816
D5S81813
D7S8209,11
D8S117914,15
FGA23
Penta D9
Penta E16,19
TH018
TPOX9
vWA17
Publications

PubMed=9033653; DOI=10.1002/(SICI)1097-0215(19970207)70:4<443::AID-IJC12>3.0.CO;2-G
Park J.-G., Yang H.-K., Kim W.-H., Chung J.-K., Kang M.-S., Lee J.-H., Oh J.-H., Park H.-S., Yeo K.-S., Kang S.H., Song S.-Y., Kang Y.K., Bang Y.-J., Kim Y.I., Kim J.-P.
Establishment and characterization of human gastric carcinoma cell lines.
Int. J. Cancer 70:443-449(1997)

PubMed=10812166; DOI=10.1016/S0165-4608(99)00217-4
Chun Y.-H., Kil J.-I., Suh Y.-S., Kim S.-H., Kim H., Park S.-H.
Characterization of chromosomal aberrations in human gastric carcinoma cell lines using chromosome painting.
Cancer Genet. Cytogenet. 119:18-25(2000)

PubMed=15723654; DOI=10.1111/j.1349-7006.2005.00016.x
Takada H., Imoto I., Tsuda H., Sonoda I., Ichikura T., Mochizuki H., Okanoue T., Inazawa J.
Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.
Cancer Sci. 96:100-110(2005)

PubMed=19956504; DOI=10.4143/crt.2005.37.1.1
Ku J.-L., Park J.-G.
Biology of SNU cell lines.
Cancer Res. Treat. 37:1-19(2005)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24807215; DOI=10.1038/ncomms4830
Liu J., McCleland M., Stawiski E.W., Gnad F., Mayba O., Haverty P.M., Durinck S., Chen Y.-J., Klijn C., Jhunjhunwala S., Lawrence M., Liu H., Wan Y., Chopra V., Yaylaoglu M.B., Yuan W., Ha C., Gilbert H.N., Reeder J., Pau G., Stinson J., Stern H.M., Manning G., Wu T.D., Neve R.M., de Sauvage F.J., Modrusan Z., Seshagiri S., Firestein R., Zhang Z.
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
Nat. Commun. 5:3830-3830(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

Cross-references
Cell line collections KCLB; 00668
Cell line databases/resources CCLE; SNU668_STOMACH
CGH-DB; 128-1
CGH-DB; 9016-4
Ontologies EFO; EFO_0006759
Biological sample resources BioSample; SAMN03473141
Gene expression databases GEO; GSM888725
GEO; GSM1374897
Polymorphism and mutation databases Cosmic; 685593
Cosmic; 921602
Cosmic; 1066232
Cosmic; 1294956
Cosmic; 1528879
Cosmic; 2484962