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Cellosaurus SNU-719 (CVCL_5086)

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Cell line name SNU-719
Synonyms SNU719; NCI-SNU-719
Accession CVCL_5086
Resource Identification Initiative To cite this cell line use: SNU-719 (RRID:CVCL_5086)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: Seoul National University (SNU) cell line collection.
Characteristics: Contains a complete EBV genome sequenced in PubMed=26889033.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Deep exome analysis.
Omics: Deep quantitative proteome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Has no TP53 mutation (PubMed=9033653).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*24:02,24:02
HLA-BB*52:01,07:02
HLA-CC*07:02,12:02
Class II
HLA-DQDQB1*05:01,05:01
HLA-DRDRB1*15:02,01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American1.31
East Asian, North60.01
East Asian, South38.67
South Asian0
European, North0
European, South0
Disease Gastric tubular adenocarcinoma (NCIt: C5473)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_L052 (SNU-719-5FU)CVCL_L053 (SNU-719-DOX)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): KCLB; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO12
D3S135815
D5S81811,12
D7S82010,11
D8S117912
D13S31710,11
D16S5399,10
D18S5113,15
D21S1129,30
FGA21,23
Penta D10,11
Penta E11,16
TH017,9
TPOX8,9
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=9033653; DOI=10.1002/(SICI)1097-0215(19970207)70:4<443::AID-IJC12>3.0.CO;2-G
Park J.-G., Yang H.-K., Kim W.-H., Chung J.-K., Kang M.-S., Lee J.-H., Oh J.-H., Park H.-S., Yeo K.-S., Kang S.H., Song S.-Y., Kang Y.K., Bang Y.-J., Kim Y.I., Kim J.-P.
Establishment and characterization of human gastric carcinoma cell lines.
Int. J. Cancer 70:443-449(1997)

PubMed=10812166; DOI=10.1016/S0165-4608(99)00217-4
Chun Y.-H., Kil J.-I., Suh Y.-S., Kim S.-H., Kim H., Park S.-H.
Characterization of chromosomal aberrations in human gastric carcinoma cell lines using chromosome painting.
Cancer Genet. Cytogenet. 119:18-25(2000)

PubMed=15016554; DOI=10.1016/j.virol.2003.12.005
Oh S.T., Seo J.S., Moon U.Y., Kang K.H., Shin D.-J., Yoon S.K., Kim W.-H., Park J.-G., Lee S.K.
A naturally derived gastric cancer cell line shows latency I Epstein-Barr virus infection closely resembling EBV-associated gastric cancer.
Virology 320:330-336(2004)

PubMed=15723654; DOI=10.1111/j.1349-7006.2005.00016.x
Takada H., Imoto I., Tsuda H., Sonoda I., Ichikura T., Mochizuki H., Okanoue T., Inazawa J.
Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.
Cancer Sci. 96:100-110(2005)

PubMed=19956504; DOI=10.4143/crt.2005.37.1.1
Ku J.-L., Park J.-G.
Biology of SNU cell lines.
Cancer Res. Treat. 37:1-19(2005)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24807215; DOI=10.1038/ncomms4830
Liu J., McCleland M., Stawiski E.W., Gnad F., Mayba O., Haverty P.M., Durinck S., Chen Y.-J., Klijn C., Jhunjhunwala S., Lawrence M., Liu H., Wan Y., Chopra V., Yaylaoglu M.B., Yuan W., Ha C., Gilbert H.N., Reeder J., Pau G., Stinson J., Stern H.M., Manning G., Wu T.D., Neve R.M., de Sauvage F.J., Modrusan Z., Seshagiri S., Firestein R., Zhang Z.
Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
Nat. Commun. 5:3830-3830(2014)

PubMed=25960936; DOI=10.4161/21624011.2014.954893
Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:E954893-E954893(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=26889033; DOI=10.1128/JVI.00060-16
Kanda T., Furuse Y., Oshitani H., Kiyono T.
Highly efficient CRISPR/Cas9-mediated cloning and functional characterization of gastric cancer-derived Epstein-Barr virus strains.
J. Virol. 90:4383-4393(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E., Schweppe D.K., Jedrychowski M., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402(2020)

Cross-references
Cell line collections KCLB; 00719
Cell line databases/resources CCLE; SNU719_STOMACH
Cell_Model_Passport; SIDM01450
CGH-DB; 129-1
CGH-DB; 9017-4
DepMap; ACH-000898
Ontologies EFO; EFO_0006760
Biological sample resources BioSample; SAMN03473188
BioSample; SAMN10988060
Chemistry resources PharmacoDB; SNU719_1479_2019
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
GEO; GSM552375
GEO; GSM888727
Other Wikidata; Q54955255
Polymorphism and mutation databases Cosmic; 685594
Cosmic; 848144
Cosmic; 869512
Cosmic; 921603
Cosmic; 1090458
Cosmic; 1294959
Cosmic; 1528880
Cosmic; 2646594
IARC_TP53; 30169
LiGeA; CCLE_869
Entry history
Entry creation04-Apr-2012
Last entry updated12-Mar-20
Version number23