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Cellosaurus SNU-81 (CVCL_5098)

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Cell line name SNU-81
Synonyms SNU81; NCI-SNU-81
Accession CVCL_5098
Resource Identification Initiative To cite this cell line use: SNU-81 (RRID:CVCL_5098)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: Seoul National University (SNU) cell line collection.
Population: Korean.
Doubling time: 30 hours (PubMed=10362137).
Microsatellite instability: Stable (MSS) (PubMed=10674020; PubMed=25926053; Sanger).
Omics: Deep exome analysis.
Omics: Deep quantitative phosphoproteome analysis.
Omics: Deep quantitative proteome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Derived from sampling site: Colon.
Sequence variations Mutation; HGNC; 583; APC; Simple; p.Ser1392Ter (c.4175C>A); ClinVar=VCV000188240; Zygosity=Heterozygous (CCLE; Cosmic-CLP).
Mutation; HGNC; 583; APC; Simple; p.Arg1450Ter (c.4348C>T); ClinVar=VCV000194585; Zygosity=Heterozygous (CCLE; Cosmic-CLP).
Mutation; HGNC; 583; APC; Simple; p.Arg2204Ter (c.6610C>T); ClinVar=VCV000236632; Zygosity=Heterozygous (CCLE; Cosmic-CLP).
Mutation; HGNC; 16712; FBXW7; Simple; p.Arg479Gln (c.1436G>A); ClinVar=VCV000376419; Zygosity=Heterozygous (CCLE; Cosmic-CLP).
Mutation; HGNC; 6407; KRAS; Simple; p.Ala146Thr (c.436G>A); ClinVar=VCV000197243; Zygosity=Heterozygous (CCLE; Cosmic-CLP).
Mutation; HGNC; 9588; PTEN; Simple; p.Arg130Gln (c.389G>A); ClinVar=VCV000007829; Zygosity=Heterozygous (CCLE; Cosmic-CLP).
Mutation; HGNC; 9588; PTEN; Simple; p.Glu299Ter (c.895G>T); ClinVar=VCV000428263; Zygosity=Heterozygous (CCLE; Cosmic-CLP).
Mutation; HGNC; 11602; TBX3; Simple; p.Glu111Ter (c.331G>T); Zygosity=Heterozygous (CCLE; Cosmic-CLP).
Mutation; HGNC; 11602; TBX3; Simple; c.942-1G>T; Zygosity=Heterozygous; Note=Splice acceptor mutation (CCLE; Cosmic-CLP).
Mutation; HGNC; 11998; TP53; Simple; p.Lys132Thr (c.395A>C); Zygosity=Heterozygous (CCLE; Cosmic-CLP).
Mutation; HGNC; 11998; TP53; Simple; p.Arg213Ter (c.637C>T); ClinVar=VCV000043590; Zygosity=Heterozygous (CCLE; Cosmic-CLP).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American1.37
East Asian, North56.62
East Asian, South42
South Asian0
European, North0
European, South0
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; KCLB; PubMed=25926053

Markers:
AmelogeninX (Cosmic-CLP; PubMed=25926053)
X,Y (KCLB)
CSF1PO11,13
D3S135815,16
D5S81810,11
D7S82012
D13S3179,10
D16S5399,12
D21S1130,31
FGA19,25
TH017,9
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=10362137; DOI=10.1002/(SICI)1097-0215(19990611)81:6<902::AID-IJC11>3.0.CO;2-T
Oh J.-H., Ku J.-L., Yoon K.-A., Kwon H.-J., Kim W.-H., Park H.-S., Yeo K.-S., Song S.-Y., Chung J.-K., Park J.-G.
Establishment and characterization of 12 human colorectal-carcinoma cell lines.
Int. J. Cancer 81:902-910(1999)

PubMed=10674020; DOI=10.1016/S0959-8049(99)00206-3
Ku J.-L., Yoon K.-A., Kim D.-Y., Park J.-G.
Mutations in hMSH6 alone are not sufficient to cause the microsatellite instability in colorectal cancer cell lines.
Eur. J. Cancer 35:1724-1729(1999)

PubMed=19956504; DOI=10.4143/crt.2005.37.1.1
Ku J.-L., Park J.-G.
Biology of SNU cell lines.
Cancer Res. Treat. 37:1-19(2005)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002-7002(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28854368; DOI=10.1016/j.celrep.2017.08.010
Roumeliotis T.I., Williams S.P., Goncalves E., Alsinet C., Del Castillo Velasco-Herrera M., Aben N., Ghavidel F.Z., Michaut M., Schubert M., Price S., Wright J.C., Yu L., Yang M., Dienstmann R., Guinney J., Beltrao P., Brazma A., Pardo M., Stegle O., Adams D.J., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Choudhary J.S.
Genomic determinants of protein abundance variation in colorectal cancer cells.
Cell Rep. 20:2201-2214(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections KCLB; 00081
Cell line databases/resources CCLE; SNU81_LARGE_INTESTINE
Cell_Model_Passport; SIDM00193
ColonAtlas; SNU81
Cosmic-CLP; 1660036
DepMap; ACH-000991
Biological sample resources BioSample; SAMN10988062
Chemistry resources GDSC; 1660036
PharmacoDB; SNU81_1483_2019
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM888730
GEO; GSM1448159
GEO; GSM1670475
Other Wikidata; Q54955273
Polymorphism and mutation databases Cosmic; 738853
Cosmic; 2612374
Cosmic; 2651851
IARC_TP53; 28338
LiGeA; CCLE_695
Progenetix; CVCL_5098
Proteomic databases PRIDE; PXD005235
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number24