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Cellosaurus SNU-869 (CVCL_5101)

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Cell line name SNU-869
Synonyms SNU869
Accession CVCL_5101
Resource Identification Initiative To cite this cell line use: SNU-869 (RRID:CVCL_5101)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: Seoul National University (SNU) cell line collection.
Part of: TCGA-110-CL cell line panel.
Doubling time: 48 hours (PubMed=12107841).
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: Deep RNAseq analysis.
Sequence variations Homozygous for KRAS p.Gly12Asp (c.35G>A) (ClinVar=VCV000012582) (CCLE).
Heterozygous for PIK3CA p.Glu545Asp (c.1635G>T) (CCLE).
TP53 p.Asp48Gly (c.143A>G) (PubMed=12107841).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North64.53
East Asian, South0
South Asian0
European, North0
European, South19.53
Disease Ampulla of Vater adenocarcinoma (NCIt: C6650)
Carcinoma of the ampulla of Vater (ORDO: Orphanet_300557)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): KCLB


Run an STR similarity search on this cell line

PubMed=12107841; DOI=10.1038/sj.bjc.6600440
Ku J.-L., Yoon K.-A., Kim I.-J., Kim W.-H., Jang J.-Y., Suh K.-S., Kim S.-W., Park Y.-H., Hwang J.-H., Yoon Y.-B., Park J.-G.
Establishment and characterisation of six human biliary tract cancer cell lines.
Br. J. Cancer 87:187-193(2002)

PubMed=19956504; DOI=10.4143/crt.2005.37.1.1
Ku J.-L., Park J.-G.
Biology of SNU cell lines.
Cancer Res. Treat. 37:1-19(2005)

Zach S., Birgin E., Ruckert F.
Primary cholangiocellular carcinoma cell lines.
J. Stem Cell Res. Transplant. 2:1013-1013(2015)

PubMed=26951071; DOI=10.1186/s12885-016-2193-5
Lai Z.W., Bolm L., Fuellgraf H., Biniossek M.L., Makowiec F., Hopt U.T., Werner M., Keck T., Bausch D., Sorio C., Scarpa A., Schilling O., Bronsert P., Wellner U.F.
Characterization of various cell lines from different ampullary cancer subtypes and cancer associated fibroblast-mediated responses.
BMC Cancer 16:195-195(2016)

PubMed=27231123; DOI=10.1158/2159-8290.CD-15-1442
Saha S.K., Gordan J.D., Kleinstiver B.P., Vu P., Najem M.S., Yeo J.-C., Shi L., Kato Y., Levin R.S., Webber J.T., Damon L.J., Egan R.K., Greninger P., McDermott U., Garnett M.J., Jenkins R.L., Rieger-Christ K.M., Sullivan T.B., Hezel A.F., Liss A.S., Mizukami Y., Goyal L., Ferrone C.R., Zhu A.X., Joung J.K., Shokat K.M., Benes C.H., Bardeesy N.
Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC dependence in intrahepatic cholangiocarcinoma.
Cancer Discov. 6:727-739(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31395879; DOI=10.1038/s41467-019-11415-2
Yu K., Chen B., Aran D., Charalel J., Yau C., Wolf D.M., van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
Nat. Commun. 10:3574-3574(2019)

Cell line collections KCLB; 00869
Cell line databases/resources CCLE; SNU869_BILIARY_TRACT
Cell_Model_Passport; SIDM00159
DepMap; ACH-000182
Biological sample resources BioSample; SAMN10988091
Chemistry resources PharmacoDB; SNU869_1485_2019
Gene expression databases ArrayExpress; E-MTAB-2770
Other Wikidata; Q54955278
Polymorphism and mutation databases Cosmic; 738872
Cosmic; 2674054
IARC_TP53; 17161
LiGeA; CCLE_931
Proteomic databases PRIDE; PXD002657
Entry history
Entry creation04-Apr-2012
Last entry updated02-Jul-2020
Version number22