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Cellosaurus SNU-C4 (CVCL_5111)

[Text version]

Cell line name SNU-C4
Synonyms SNU C4; SNUC4; NCI-SNU-C4; C4
Accession CVCL_5111
Resource Identification Initiative To cite this cell line use: SNU-C4 (RRID:CVCL_5111)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: Seoul National University (SNU) cell line collection.
Microsatellite instability: Instable (MSI) (PubMed=10674020; PubMed=25926053; PubMed=31068700).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: SNU-4c; Occasionally.
Sequence variations Homozygous for MSH6 p.Phe1088Serfs*2 (c.3261delC) (PubMed=10674020).
Heterozygous for PTEN p.Glu288fs*3 (c.863delA) (CCLE).
Homozygous for TGFBR2 p.Lys128Serfs*35 (c.374delA) (PubMed=10674020).
Heterozygous for TP53 p.Gly245Ser (c.733G>A) (ClinVar=VCV000012365) (CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.62
East Asian, North57.31
East Asian, South42.07
South Asian0
European, North0
European, South0
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): KCLB; PubMed=25926053

Markers:
AmelogeninX,Y
CSF1PO10
D3S135816,20
D5S8188,9
D7S8208 (KCLB)
7.3,11,12 (PubMed=25926053)
D13S3178,9
D16S5399,10
D21S1128,30
FGA20,21
TH017,9 (KCLB)
7,8 (PubMed=25926053)
TPOX11
vWA14,15

Run an STR similarity search on this cell line
Publications

PubMed=3479249
Park J.-G., Oie H.K., Sugarbaker P.H., Henslee J.G., Chen T.-R., Johnson B.E., Gazdar A.F.
Characteristics of cell lines established from human colorectal carcinoma.
Cancer Res. 47:6710-6718(1987)

PubMed=8556707; DOI=10.1016/S0304-3835(06)80030-3
Rand A., Glenn K.S., Alvares C.P., White M.B., Thibodeau S.M., Karnes W.E. Jr.
p53 functional loss in a colon cancer cell line with two missense mutations (218leu and 248trp) on separate alleles.
Cancer Lett. 98:183-191(1996)

PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. 63 Suppl. 24:32-91(1996)

PubMed=8806095; DOI=10.1002/jcb.240630508
Park J.-G., Gazdar A.F.
Biology of colorectal and gastric cancer cell lines.
J. Cell. Biochem. 63 Suppl. 24:131-141(1996)

PubMed=10674020; DOI=10.1016/S0959-8049(99)00206-3
Ku J.-L., Yoon K.-A., Kim D.-Y., Park J.-G.
Mutations in hMSH6 alone are not sufficient to cause the microsatellite instability in colorectal cancer cell lines.
Eur. J. Cancer 35:1724-1729(1999)

PubMed=19956504; DOI=10.4143/crt.2005.37.1.1
Ku J.-L., Park J.-G.
Biology of SNU cell lines.
Cancer Res. Treat. 37:1-19(2005)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24755471; DOI=10.1158/0008-5472.CAN-14-0013
Mouradov D., Sloggett C., Jorissen R.N., Love C.G., Li S., Burgess A.W., Arango D., Strausberg R.L., Buchanan D., Wormald S., O'Connor L., Wilding J.L., Bicknell D.C., Tomlinson I.P.M., Bodmer W.F., Mariadason J.M., Sieber O.M.
Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer.
Cancer Res. 74:3238-3247(2014)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002-7002(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections KCLB; 0000C4
Cell line databases/resources CCLE; SNUC4_LARGE_INTESTINE
Cell_Model_Passport; SIDM00500
ColonAtlas; SNUC4
DepMap; ACH-000959
Biological sample resources BioSample; SAMN10987757
Chemistry resources ChEMBL-Cells; CHEMBL3307457
ChEMBL-Targets; CHEMBL614933
PharmacoDB; SNUC4_1492_2019
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887645
GEO; GSM888737
GEO; GSM1448127
Other Wikidata; Q54955294
Polymorphism and mutation databases Cosmic; 848825
Cosmic; 2302011
Cosmic; 2651863
IARC_TP53; 28310
LiGeA; CCLE_420
Entry history
Entry creation04-Apr-2012
Last entry update02-Jul-2020
Version number25