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Cellosaurus ACC-MESO-4 (CVCL_5114)

Cell line name ACC-MESO-4
Synonyms ACC-Meso-4; MESO-4
Accession CVCL_5114
Resource Identification Initiative To cite this cell line use: ACC-MESO-4 (RRID:CVCL_5114)
Comments Population: Japanese.
Transformant: ChEBI; CHEBI:46661; Asbestos.
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Lung, pleura; UBERON=UBERON_0000977.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=16630136).
  • Mutation; HGNC; 950; BAP1; Simple; p.Tyr724Ter (c.2172delC); Zygosity=Unspecified (PubMed=26011428).
  • Mutation; HGNC; 20796; RASSF6; Simple; p.Arg155fs (c.464_465insA); Zygosity=Unspecified (PubMed=25902174).
Disease Pleural epithelioid mesothelioma (NCIt: C45662)
Pleural mesothelioma (ORDO: Orphanet_50251)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
STR profile Source(s): RCB


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PubMed=16630136; DOI=10.1111/j.1349-7006.2006.00184.x
Usami N., Fukui T., Kondo M., Taniguchi T., Yokoyama T., Mori S., Yokoi K., Horio Y., Shimokata K., Sekido Y., Hida T.
Establishment and characterization of four malignant pleural mesothelioma cell lines from Japanese patients.
Cancer Sci. 97:387-394(2006)

PubMed=17270034; DOI=10.1111/j.1349-7006.2006.00386.x
Taniguchi T., Karnan S., Fukui T., Yokoyama T., Tagawa H., Yokoi K., Ueda Y., Mitsudomi T., Horio Y., Hida T., Yatabe Y., Seto M., Sekido Y.
Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p32.
Cancer Sci. 98:438-446(2007)

PubMed=21245096; DOI=10.1158/0008-5472.CAN-10-2164
Murakami H., Mizuno T., Taniguchi T., Fujii M., Ishiguro F., Fukui T., Akatsuka S., Horio Y., Hida T., Kondo Y., Toyokuni S., Osada H., Sekido Y.
LATS2 is a tumor suppressor gene of malignant mesothelioma.
Cancer Res. 71:873-883(2011)

PubMed=25902174; DOI=10.1097/JTO.0000000000000493
Miyanaga A., Masuda M., Tsuta K., Kawasaki K., Nakamura Y., Sakuma T., Asamura H., Gemma A., Yamada T.
Hippo pathway gene mutations in malignant mesothelioma: revealed by RNA and targeted exon sequencing.
J. Thorac. Oncol. 10:844-851(2015)

PubMed=26011428; DOI=10.1111/cas.12698
Hakiri S., Osada H., Ishiguro F., Murakami H., Murakami-Tonami Y., Yokoi K., Sekido Y.
Functional differences between wild-type and mutant-type BRCA1-associated protein 1 tumor suppressor against malignant mesothelioma cells.
Cancer Sci. 106:990-999(2015)

PubMed=28553954; DOI=10.1038/onc.2017.147
Kato T., Sato T., Yokoi K., Sekido Y.
E-cadherin expression is correlated with focal adhesion kinase inhibitor resistance in merlin-negative malignant mesothelioma cells.
Oncogene 36:5522-5531(2017)

Cell line collections (Providers) RCB; RCB2293
Cell line databases/resources CLO; CLO_0050083
cancercelllines; CVCL_5114
Biological sample resources BioSample; SAMN03471959
Encyclopedic resources Wikidata; Q54608246
Gene expression databases GEO; GSM551968
GEO; GSM850297
Polymorphism and mutation databases Cosmic; 877274
Cosmic; 1481541
Cosmic; 2759003
Cosmic; 2759232
IARC_TP53; 24549
Progenetix; CVCL_5114
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number20