ID   HCC2429
AC   CVCL_5132
SY   HCC-2429; Hamon Cancer Center 2429
DR   BioSample; SAMN10989601
DR   cancercelllines; CVCL_5132
DR   Cell_Model_Passport; SIDM01601
DR   Cosmic; 903644
DR   Cosmic; 1146931
DR   Cosmic; 1340147
DR   Cosmic; 1518099
DR   DepMap; ACH-000143
DR   GEO; GSM171900
DR   GEO; GSM171901
DR   GEO; GSM253412
DR   GEO; GSM434319
DR   GEO; GSM794394
DR   IGRhCellID; HCC2429GEO
DR   Progenetix; CVCL_5132
DR   Wikidata; Q54881655
RX   PubMed=10944559;
RX   PubMed=15994877;
RX   PubMed=20679594;
RX   PubMed=24736545;
RX   PubMed=28196595;
RX   PubMed=29348827;
RX   PubMed=29681454;
RX   PubMed=31068700;
RX   PubMed=31803961;
WW   https://tcpaportal.org/mclp/
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: MD Anderson Cell Lines Project.
CC   Sequence variation: Gene fusion; HGNC; 13575; BRD4 + HGNC; 29919; NUTM1; Name(s)=BRD4-NUTM1, BRD4-NUT (PubMed=15994877; PubMed=29348827).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg267Gln (c.800G>A); ClinVar=VCV000127823; Zygosity=Homozygous (DepMap).
CC   Omics: Deep exome analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Misspelling: HCC-2425; PubMed=29348827; Note=In table of supplementary material.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
ST   Source(s): PubMed=20679594
ST   Amelogenin: X
ST   CSF1PO: 10,13
ST   D13S317: 11
ST   D16S539: 11,13
ST   D5S818: 12,14
ST   D7S820: 10,11
ST   TH01: 6,9
ST   TPOX: 8
ST   vWA: 16
DI   NCIt; C2926; Lung non-small cell carcinoma
DI   NCIt; C45716; NUT carcinoma
DI   ORDO; Orphanet_443167; NUT midline carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_V989 ! HCC2429 BL
SX   Female
AG   34Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 22
//
RX   PubMed=10944559; DOI=10.1093/jnci/92.16.1355;
RA   Dang T.P., Gazdar A.F., Virmani A.K., Sepetavec T., Hande K.R.,
RA   Minna J.D., Roberts J.R., Carbone D.P.;
RT   "Chromosome 19 translocation, overexpression of Notch3, and human lung
RT   cancer.";
RL   J. Natl. Cancer Inst. 92:1355-1357(2000).
//
RX   PubMed=15994877; DOI=10.1136/jmg.2004.029686;
RA   Haruki N., Kawaguchi K.S., Eichenberger S., Massion P.P., Gonzalez A.,
RA   Gazdar A.F., Minna J.D., Carbone D.P., Dang T.P.;
RT   "Cloned fusion product from a rare t(15;19)(q13.2;p13.1) inhibit S
RT   phase in vitro.";
RL   J. Med. Genet. 42:558-564(2005).
//
RX   PubMed=20679594; DOI=10.1093/jnci/djq279;
RA   Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.;
RT   "Lung cancer cell lines as tools for biomedical discovery and
RT   research.";
RL   J. Natl. Cancer Inst. 102:1310-1321(2010).
//
RX   PubMed=24736545; DOI=10.1158/0008-5472.CAN-13-2658;
RA   Wang R.-R., Liu W., Helfer C.M., Bradner J.E., Hornick J.L.,
RA   Janicki S.M., French C.A., You J.-X.;
RT   "Activation of SOX2 expression by BRD4-NUT oncogenic fusion drives
RT   neoplastic transformation in NUT midline carcinoma.";
RL   Cancer Res. 74:3332-3343(2014).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=29348827; DOI=10.18632/oncotarget.22862;
RA   Stirnweiss A., Oommen J., Kotecha R.S., Kees U.R., Beesley A.H.;
RT   "Molecular-genetic profiling and high-throughput in vitro drug
RT   screening in NUT midline carcinoma-an aggressive and fatal disease.";
RL   Oncotarget 8:112313-112329(2017).
//
RX   PubMed=29681454; DOI=10.1016/j.cell.2018.03.028;
RA   McMillan E.A., Ryu M.-J., Diep C.H., Mendiratta S., Clemenceau J.R.,
RA   Vaden R.M., Kim J.-H., Motoyaji T., Covington K.R., Peyton M.,
RA   Huffman K., Wu X.-F., Girard L., Sung Y., Chen P.-H., Mallipeddi P.L.,
RA   Lee J.Y., Hanson J., Voruganti S., Yu Y., Park S., Sudderth J.,
RA   DeSevo C., Muzny D.M., Doddapaneni H., Gazdar A.F., Gibbs R.A.,
RA   Hwang T.H., Heymach J.V., Wistuba I.I., Coombes K.R., Williams N.S.,
RA   Wheeler D.A., MacMillan J.B., DeBerardinis R.J., Roth M.G.,
RA   Posner B.A., Minna J.D., Kim H.S., White M.A.;
RT   "Chemistry-first approach for nomination of personalized treatment in
RT   lung cancer.";
RL   Cell 173:864-878.e29(2018).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=31803961; DOI=10.1002/jcb.29564;
RA   Mulshine J.L., Ujhazy P., Antman M., Burgess C.M., Kuzmin I.A.,
RA   Bunn P.A. Jr., Johnson B.E., Roth J.A., Pass H.I., Ross S.M.,
RA   Aldige C.R., Wistuba I.I., Minna J.D.;
RT   "From clinical specimens to human cancer preclinical models -- a journey
RT   the NCI-cell line database-25 years later.";
RL   J. Cell. Biochem. 121:3986-3999(2020).
//