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Cellosaurus K562/MTX-2 (CVCL_5144)

[Text version]

Cell line name K562/MTX-2
Accession CVCL_5144
Resource Identification Initiative To cite this cell line use: K562/MTX-2 (RRID:CVCL_5144)
Comments Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
Derived from sampling site: Pleural effusion.
Sequence variations BCR-ABL1 gene fusion (from parent cell line).
Homozygous for TP53 p.Gln136fs*13 (c.406_407insC) (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0004 (K-562)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): RCB

Markers:
AmelogeninX
CSF1PO9,10
D5S81811,12
D7S8209,11
D13S3178
D16S53911,12
TH016,9.3
TPOX8,9
vWA16

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Publications

PubMed=2465288; DOI=10.1111/j.1349-7006.1988.tb01549.x
Koizumi S.
Impairment of methotrexate (MTX)-polyglutamate formation of MTX-resistant K562 cell lines.
Jpn. J. Cancer Res. 79:1230-1237(1988)

Cross-references
Cell line collections RCB; RCB0474
Ontologies CLO; CLO_0050119
Biological sample resources BioSample; SAMN03472320
Other Wikidata; Q54899414
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number15