Home  |  Contact

Cellosaurus NCI-H2887 (CVCL_5159)

[Text version]

Cell line name NCI-H2887
Synonyms H2887; H-2887; NCIH2887
Accession CVCL_5159
Resource Identification Initiative To cite this cell line use: NCI-H2887 (RRID:CVCL_5159)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Omics: Deep exome analysis.
Omics: miRNA expression profiling.
Omics: Protein expression by reverse-phase protein arrays.
Sequence variations Heterozygous for KRAS p.Gly12Val (c.35G>T) (CCLE).
Homozygous for TP53 p.Ser127Phe (c.380C>T) (CCLE).
Disease Squamous cell lung carcinoma (NCIt: C3493)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_S845 ! NCI-BL2887
Sex of cell Male
Age at sampling 31Y
Category Cancer cell line
STR profile Source(s): PubMed=20679594

Markers:
AmelogeninX
CSF1PO11,12
D5S81810,11
D7S82012
D13S3178
D16S53911
TH016,9.3
TPOX12
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=10987304
Girard L., Zochbauer-Muller S., Virmani A.K., Gazdar A.F., Minna J.D.
Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering.
Cancer Res. 60:4894-4906(2000)

PubMed=11314036; DOI=10.1038/sj.onc.1204211
Forgacs E., Wren J.D., Kamibayashi C., Kondo M., Xu X.L., Markowitz S.D., Tomlinson G.E., Muller C.Y., Gazdar A.F., Garner H.R., Minna J.D.
Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers.
Oncogene 20:1005-1009(2001)

PubMed=12759538; DOI=10.1159/000070299
Fujishita T., Loda M., Turner R.E., Gentler M., Kashii T., Breathnach O.S., Johnson B.E.
Sensitivity of non-small-cell lung cancer cell lines established from patients treated with prolonged infusions of paclitaxel.
Oncology 64:399-406(2003)

PubMed=20624269; DOI=10.1186/1756-9966-29-75
Du L., Schageman J.J., Irnov I., Girard L., Hammond S.M., Minna J.D., Gazdar A.F., Pertsemlidis A.
MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs.
J. Exp. Clin. Cancer Res. 29:75-75(2010)

PubMed=20679594; DOI=10.1093/jnci/djq279
Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.
Lung cancer cell lines as tools for biomedical discovery and research.
J. Natl. Cancer Inst. 102:1310-1321(2010)

PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112
Byers L.A., Wang J., Nilsson M.B., Fujimoto J., Saintigny P., Yordy J., Giri U., Peyton M., Fan Y.H., Diao L., Masrorpour F., Shen L., Liu W., Duchemann B., Tumula P., Bhardwaj V., Welsh J., Weber S., Glisson B.S., Kalhor N., Wistuba I.I., Girard L., Lippman S.M., Mills G.B., Coombes K.R., Weinstein J.N., Minna J.D., Heymach J.V.
Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.
Cancer Discov. 2:798-811(2012)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections NCI-DTP; NCI-H2887
Cell line databases/resources CCLE; NCIH2887_LUNG
Cell_Model_Passport; SIDM01384
DepMap; ACH-000251
IGRhCellID; H2887GEO
Biological sample resources BioSample; SAMN10989612
Gene expression databases GEO; GSM253355
GEO; GSM434256
GEO; GSM794369
Other Wikidata; Q54908012
Polymorphism and mutation databases Cosmic; 903622
Cosmic; 1146911
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number16