Cellosaurus NCI-H3122 (CVCL_5160)

Cell line name NCI-H3122
Synonyms H3122; H-3122; NCIH3122
Accession CVCL_5160
Resource Identification Initiative To cite this cell line use: NCI-H3122 (RRID:CVCL_5160)
Comments Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep proteome analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_4Y37 (H3122 CHR-A1); CVCL_AY53 (H3122 CR1)
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; PubMed=20679594

Markers:
AmelogeninX
CSF1PO11,12
D13S31710,12
D16S53911,12
D5S81811,12
D7S8208,12
TH017,9.3
TPOX10
vWA16
Publications

PubMed=11030152; DOI=10.1038/sj.onc.1203815
Modi S., Kubo A., Oie H., Coxon A.B., Rehmatulla A., Kaye F.J.
Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.
Oncogene 19:4632-4639(2000)

PubMed=12759538; DOI=10.1159/000070299
Fujishita T., Loda M., Turner R.E., Gentler M., Kashii T., Breathnach O.S., Johnson B.E.
Sensitivity of non-small-cell lung cancer cell lines established from patients treated with prolonged infusions of paclitaxel.
Oncology 64:399-406(2003)

PubMed=20679594; DOI=10.1093/jnci/djq279
Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.
Lung cancer cell lines as tools for biomedical discovery and research.
J. Natl. Cancer Inst. 102:1310-1321(2010)

PubMed=24675041; DOI=10.1158/2159-8290.CD-13-0846
Friboulet L., Li N., Katayama R., Lee C.C., Gainor J.F., Crystal A.S., Michellys P.-Y., Awad M.M., Yanagitani N., Kim S., Pferdekamper A.C., Li J., Kasibhatla S., Sun F., Sun X., Hua S., McNamara P., Mahmood S., Lockerman E.L., Fujita N., Nishio M., Harris J.L., Shaw A.T., Engelman J.A.
The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer.
Cancer Discov. 4:662-673(2014)

PubMed=26361996; DOI=10.1016/j.jprot.2015.09.003
Grundner-Culemann K., Dybowski J.N., Klammer M., Tebbe A., Schaab C., Daub H.
Comparative proteome analysis across non-small cell lung cancer cell lines.
J. Proteomics 130:1-10(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections NCI-DTP; NCI-H3122
Cell line databases/resources Cosmic-CLP; 1240190
GDSC; 1240190
IGRhCellID; H3122GEO
LINCS_LDP; LCL-1675
Gene expression databases GEO; GSM253349
GEO; GSM434307
GEO; GSM794370
GEO; GSM1374739
GEO; GSM1374740
GEO; GSM1670238
Polymorphism and mutation databases Cosmic; 755472
Cosmic; 914951
Cosmic; 1146912
Cosmic; 2245571
Proteomic databases PRIDE; PXD002556