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Cellosaurus SH-10-TC (CVCL_5167)

[Text version]

Cell line name SH-10-TC
Synonyms SH10TC; SH-10
Accession CVCL_5167
Resource Identification Initiative To cite this cell line use: SH-10-TC (RRID:CVCL_5167)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Population: Japanese.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for KRAS p.Gly12Val (c.35G>T) (ClinVar=VCV000012583) (CCLE).
TERT c.1-124C>T (c.228C>T) (C228T); Note=In promoter (PubMed=31068700).
Homozygous for TP53 p.Arg273Cys (c.817C>T) (ClinVar=VCV000043594) (CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North64.56
East Asian, South34.04
South Asian0
European, North0
European, South1.4
Disease Gastric mucinous adenocarcinoma (NCIt: C5248)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Category Cancer cell line
STR profile Source(s): RCB; TKG

Markers:
AmelogeninX
CSF1PO13
D5S81812
D7S82011
D13S31711
D16S53911,13
TH017,9
TPOX8,11
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections RCB; RCB1940
TKG; TKG 0338
TKG; TKG 0412
Cell line databases/resources CCLE; SH10TC_STOMACH
Cell_Model_Passport; SIDM01343
DepMap; ACH-000764
Biological sample resources BioSample; SAMN10987814
Chemistry resources PharmacoDB; SH10TC_1372_2019
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887567
GEO; GSM888650
Other Wikidata; Q54953195
Polymorphism and mutation databases Cosmic; 889109
Cosmic; 1187292
IARC_TP53; 28235
LiGeA; CCLE_568
Progenetix; CVCL_5167
Entry history
Entry creation04-Apr-2012
Last entry update12-Jan-2021
Version number20