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Cellosaurus Y-MESO-12 (CVCL_5178)

[Text version]
Cell line name Y-MESO-12
Accession CVCL_5178
Resource Identification Initiative To cite this cell line use: Y-MESO-12 (RRID:CVCL_5178)
Comments Population: Japanese.
Omics: Array-based CGH.
Omics: Transcriptome analysis by microarray.
Donor information: No history of asbestos exposure (PubMed=17270034).
Sequence variations
  • Gene deletion; HGNC; 7773; NF2; Zygosity=Homozygous (PubMed=21245096).
Disease Pleural epithelioid mesothelioma (NCIt: C45662)
Pleural mesothelioma (ORDO: Orphanet_50251)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 71Y
Category Cancer cell line
Publications

PubMed=17270034; DOI=10.1111/j.1349-7006.2006.00386.x
Taniguchi T., Karnan S., Fukui T., Yokoyama T., Tagawa H., Yokoi K., Ueda Y., Mitsudomi T., Horio Y., Hida T., Yatabe Y., Seto M., Sekido Y.
Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p32.
Cancer Sci. 98:438-446(2007)

PubMed=19380521; DOI=10.1093/carcin/bgp097
Kawaguchi K., Murakami H., Taniguchi T., Fujii M., Kawata S., Fukui T., Kondo Y., Osada H., Usami N., Yokoi K., Ueda Y., Yatabe Y., Ito M., Horio Y., Hida T., Sekido Y.
Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells.
Carcinogenesis 30:1097-1105(2009)

PubMed=21245096; DOI=10.1158/0008-5472.CAN-10-2164
Murakami H., Mizuno T., Taniguchi T., Fujii M., Ishiguro F., Fukui T., Akatsuka S., Horio Y., Hida T., Kondo Y., Toyokuni S., Osada H., Sekido Y.
LATS2 is a tumor suppressor gene of malignant mesothelioma.
Cancer Res. 71:873-883(2011)

PubMed=22286761; DOI=10.1038/onc.2012.5
Mizuno T., Murakami H., Fujii M., Ishiguro F., Tanaka I., Kondo Y., Akatsuka S., Toyokuni S., Yokoi K., Osada H., Sekido Y.
YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes.
Oncogene 31:5117-5122(2012)

PubMed=26011428; DOI=10.1111/cas.12698
Hakiri S., Osada H., Ishiguro F., Murakami H., Murakami-Tonami Y., Yokoi K., Sekido Y.
Functional differences between wild-type and mutant-type BRCA1-associated protein 1 tumor suppressor against malignant mesothelioma cells.
Cancer Sci. 106:990-999(2015)

PubMed=28553954; DOI=10.1038/onc.2017.147
Kato T., Sato T., Yokoi K., Sekido Y.
E-cadherin expression is correlated with focal adhesion kinase inhibitor resistance in merlin-negative malignant mesothelioma cells.
Oncogene 36:5522-5531(2017)

Cross-references
Cell line collections (Providers) RCB; RCB5667
Cell line databases/resources cancercelllines; CVCL_5178
Encyclopedic resources Wikidata; Q54995138
Gene expression databases GEO; GSM552526
GEO; GSM850303
Polymorphism and mutation databases Cosmic; 2759216
Progenetix; CVCL_5178
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number18