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Cellosaurus Y-MESO-9 (CVCL_5190)

[Text version]
Cell line name Y-MESO-9
Accession CVCL_5190
Resource Identification Initiative To cite this cell line use: Y-MESO-9 (RRID:CVCL_5190)
Comments Population: Japanese.
Transformant: ChEBI; CHEBI:46661; Asbestos.
Omics: Array-based CGH.
Omics: Transcriptome analysis by microarray.
Sequence variations
  • Mutation; HGNC; 950; BAP1; Simple; p.Phe678Leufs*37 (c.2035_2036del2); Zygosity=Unspecified (PubMed=26011428).
  • Mutation; HGNC; 7773; NF2; Simple; p.Tyr177fs (c.527_528delTG); Zygosity=Unspecified (PubMed=21245096).
Disease Pleural epithelioid mesothelioma (NCIt: C45662)
Pleural mesothelioma (ORDO: Orphanet_50251)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): RCB=RCB5666

Markers:
AmelogeninX
CSF1PO10,13
D5S8189,12
D7S8209,10
D13S31710
D16S5399
TH016
TPOX11
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=17270034; DOI=10.1111/j.1349-7006.2006.00386.x
Taniguchi T., Karnan S., Fukui T., Yokoyama T., Tagawa H., Yokoi K., Ueda Y., Mitsudomi T., Horio Y., Hida T., Yatabe Y., Seto M., Sekido Y.
Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p32.
Cancer Sci. 98:438-446(2007)

PubMed=19380521; DOI=10.1093/carcin/bgp097
Kawaguchi K., Murakami H., Taniguchi T., Fujii M., Kawata S., Fukui T., Kondo Y., Osada H., Usami N., Yokoi K., Ueda Y., Yatabe Y., Ito M., Horio Y., Hida T., Sekido Y.
Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells.
Carcinogenesis 30:1097-1105(2009)

PubMed=21245096; DOI=10.1158/0008-5472.CAN-10-2164
Murakami H., Mizuno T., Taniguchi T., Fujii M., Ishiguro F., Fukui T., Akatsuka S., Horio Y., Hida T., Kondo Y., Toyokuni S., Osada H., Sekido Y.
LATS2 is a tumor suppressor gene of malignant mesothelioma.
Cancer Res. 71:873-883(2011)

PubMed=22286761; DOI=10.1038/onc.2012.5
Mizuno T., Murakami H., Fujii M., Ishiguro F., Tanaka I., Kondo Y., Akatsuka S., Toyokuni S., Yokoi K., Osada H., Sekido Y.
YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes.
Oncogene 31:5117-5122(2012)

PubMed=26011428; DOI=10.1111/cas.12698
Hakiri S., Osada H., Ishiguro F., Murakami H., Murakami-Tonami Y., Yokoi K., Sekido Y.
Functional differences between wild-type and mutant-type BRCA1-associated protein 1 tumor suppressor against malignant mesothelioma cells.
Cancer Sci. 106:990-999(2015)

PubMed=28553954; DOI=10.1038/onc.2017.147
Kato T., Sato T., Yokoi K., Sekido Y.
E-cadherin expression is correlated with focal adhesion kinase inhibitor resistance in merlin-negative malignant mesothelioma cells.
Oncogene 36:5522-5531(2017)

Cross-references
Cell line collections (Providers) RCB; RCB5666
Cell line databases/resources cancercelllines; CVCL_5190
Encyclopedic resources Wikidata; Q54995161
Gene expression databases GEO; GSM552525
GEO; GSM850301
Polymorphism and mutation databases Cosmic; 2759215
Progenetix; CVCL_5190
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number18