Cellosaurus OPM-1 (CVCL_5210)

Cell line name OPM-1
Synonyms OPM1
Accession CVCL_5210
Resource Identification Initiative To cite this cell line use: OPM-1 (RRID:CVCL_5210)
Comments Characteristics: Produces Ig lambda.
Doubling time: 36-42 hours (PubMed=3926660).
Sequence variation: FGFR3 p.Lys650Glu (PubMed=11157491).
Sequence variation: KRAS p.Lys70Ter (PubMed=11157491).
Derived from sampling site: Peripheral blood.
Disease Plasma cell myeloma (NCIt: C3242)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1625 ! OPM-2
Sex of cell Female
Category Cancer cell line

PubMed=3926660; DOI=10.1002/ijc.2910360217
Katagiri S., Yonezawa T., Kuyama J., Kanayama Y., Nishida K., Abe T., Tamaki T., Ohnishi M., Tarui S.
Two distinct human myeloma cell lines originating from one patient with myeloma.
Int. J. Cancer 36:241-246(1985)

PubMed=10087940; DOI=10.1016/S0165-4608(98)00157-5
Kuipers J., Vaandrager J.W., Weghuis D.O., Pearson P.L., Scheres J., Lokhorst H.M., Clevers H., Bast B.J.E.G.
Fluorescence in situ hybridization analysis shows the frequent occurrence of 14q32.3 rearrangements with involvement of immunoglobulin switch regions in myeloma cell lines.
Cancer Genet. Cytogenet. 109:99-107(1999)

PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2
Drexler H.G., Matsuo Y.
Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia.
Leuk. Res. 24:681-703(2000)

Chesi M., Brents L.A., Ely S.A., Bais C., Robbiani D.F., Mesri E.A., Kuehl W.M., Bergsagel P.L.
Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma.
Blood 97:729-736(2001)

PubMed=18647998; DOI=10.1093/jncimonographs/lgn011
Dib A., Gabrea A., Glebov O.K., Bergsagel P.L., Kuehl W.M.
Characterization of MYC translocations in multiple myeloma cell lines.
J. Natl. Cancer Inst. Monogr. 39:25-31(2008)

Polymorphism and mutation databases Cosmic; 720768
Cosmic; 2081431
Cosmic; 2367299