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Cellosaurus SK-BR-5 (CVCL_5217)

[Text version]

Cell line name SK-BR-5
Synonyms SK-Br-5; SKBR-5; SKBr5; SkBr5; SKBR5
Accession CVCL_5217
Resource Identification Initiative To cite this cell line use: SK-BR-5 (RRID:CVCL_5217)
Comments From: Memorial Sloan Kettering Cancer Center; New York; USA.
Omics: miRNA expression profiling.
Omics: Transcriptome analysis.
Sequence variations Homozygous for CDH1 c.532-1G>C; splice acceptor mutation (PubMed=19593635).
Homozygous for PIK3CA p.His1047Arg (c.3140A>G) (PubMed=19593635).
TP53 p.Ala161Asp (c.482C>A) (PubMed=16541312).
Disease Breast carcinoma (NCIt: C4872)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Category Cancer cell line
Publications

PubMed=6582512; DOI=10.1073/pnas.81.2.568
Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=16397213; DOI=10.1158/0008-5472.CAN-05-2853
Elstrodt F., Hollestelle A., Nagel J.H.A., Gorin M., Wasielewski M., van den Ouweland A., Merajver S.D., Ethier S.P., Schutte M.
BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants.
Cancer Res. 66:41-45(2006)

PubMed=16541312; DOI=10.1007/s10549-006-9186-z
Wasielewski M., Elstrodt F., Klijn J.G.M., Berns E.M.J.J., Schutte M.
Thirteen new p53 gene mutants identified among 41 human breast cancer cell lines.
Breast Cancer Res. Treat. 99:97-101(2006)

PubMed=19593635; DOI=10.1007/s10549-009-0460-8
Hollestelle A., Nagel J.H.A., Smid M., Lam S., Elstrodt F., Wasielewski M., Ng S.S., French P.J., Peeters J.K., Rozendaal M.J., Riaz M., Koopman D.G., ten Hagen T.L.M., de Leeuw B.H.C.G.M., Zwarthoff E.C., Teunisse A., van der Spek P.J., Klijn J.G.M., Dinjens W.N.M., Ethier S.P., Clevers H., Jochemsen A.G., den Bakker M.A., Foekens J.A., Martens J.W.M., Schutte M.
Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines.
Breast Cancer Res. Treat. 121:53-64(2010)

PubMed=23601657; DOI=10.1186/bcr3415
Riaz M., van Jaarsveld M.T.M., Hollestelle A., Prager-van der Smissen W.J.C., Heine A.A.J., Boersma A.W.M., Liu J., Helmijr J.C.A., Ozturk B., Smid M., Wiemer E.A.C., Foekens J.A., Martens J.W.M.
miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs.
Breast Cancer Res. 15:R33-R33(2013)

Cross-references
Cell line databases/resources DepMap; ACH-002329
Chemistry resources PharmacoDB; SKBR5_1384_2019
Gene expression databases GEO; GSM421884
GEO; GSM1661989
Other Wikidata; Q54953625
Polymorphism and mutation databases Cosmic; 997936
Cosmic; 1046938
Cosmic; 1287912
Cosmic; 1289406
IARC_TP53; 24347
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number17